Pinkerton School is a boarding school with two teachers. One of the teachers, Mr. Soper, is nice, and the other, Ms. Macbeth, is evil and is constantly trying to enslave the children of the school. However, four of the students act as a secret organisation known as "The Invisible Network of Kids", or "I.N.K." for short. I.N.K's mission is to thwart all of Ms. Macbeth's evil plans.
George-Albert Bordemer (son of the owner), top of the class and resourceful, shares the strangest of adventures with Rosy (daughter of the gardener), a nosy little minx -even though they have a love-hate relationship. Their hotel is often faced with the competition of Majestop, much bigger and much fancier; they thus have to rack their brains so as to lure customers.
The story follows the lives of two young people, Inuzuka Himari, who has yet to find her first love, and Natsume Yuu, a flower-loving boy, who remained best friends in their second year of high school, together in the gardening club. Sometimes Hiyori will tease him by say things like, "If Yu can't get married, I'll have to take the blame. It's hard when your brother calls him 'brother-in-law!" But when Yuu is reunited with his first crush from the past, the wheels of their relationship suddenly started to turn! Will Himari's newfound feelings help her break free from her "ideal friend" status?
A couple, Jet and Glindy, live on a planet named Jeepers, where society is uniform and artistic qualities are shunned. Jet and Glindy, meanwhile, are artists and performers. Jet's parents do not approve, and they tell Jet and Glindy that art is not everything in life. However, another boy, named Nixon, is dropped next door from a spaceship. He had been evicted from Groovenia, which he tells Jet and Glindy is a paradise for artists.
Set in Earth's far-flung future, the 3 Amigonauts follows three lovably reckless pals who attend the solar system's most prestigious space academy and super-size the smallest tasks into madcap intergalactic adventures.