Investigators Conrado and Fernando take a leave of the absence from the police force to track down Fernando's girlfriend Virginia. Virginia, a reporter, has left town and is working undercover as a barmaid in order to interview Refugio Canales, a criminal and small town municipal president. Conrado and Fernando soon call their friend Santo for help.
Unfortunately the movie Santo vs. the Diabolical Brain is not yet available on HBO Max.
| Directing | Federico Curiel | Director |
| Writing | Federico Curiel | Screenplay |
| Writing | Fernando Osés | Screenplay |
| Writing | Antonio Orellana | Screenplay |
| Camera | Fernando Colín | Director of Photography |
| Sound | Enrico C. Cabiati | Original Music Composer |
