Blackmailing a young couple to assist with his horrific experiments the Baron, desperate for vital medical data, abducts a man from an insane asylum. On route the abductee dies and the Baron and his assistant transplant his brain into a corpse. The creature is tormented by a trapped soul in an alien shell and, after a visit to his wife who violently rejects his monstrous form, the creature wreaks his revenge on the perpetrator of his misery: Baron Frankenstein.
Unfortunately the movie Frankenstein Must Be Destroyed is not yet available on HBO Max.
| Writing | Anthony Nelson Keys | Story |
| Directing | Terence Fisher | Director |
| Writing | Bert Batt | Story |
| Writing | Bert Batt | Screenplay |
| Costume & Make-Up | Eddie Knight | Makeup Artist |
| Production | Anthony Nelson Keys | Producer |
| Camera | Arthur Grant | Director of Photography |
| Production | Irene Lamb | Casting |
| Editing | Gordon Hales | Editor |
| Sound | James Bernard | Original Music Composer |
| Sound | Philip Martell | Music Director |
| Art | Bernard Robinson | Supervising Art Director |
| Costume & Make-Up | Pat McDermott | Hairstylist |
| Writing | Mary Shelley | Characters |
