Shorts from "The New Adventures of Mighty Mouse and Heckle and Jeckle" Saturday morning cartoon show edited together into a movie. Space cat villain Harry the Heartless holds space mouse Queen Pureheart. Only Mighty Mouse can save her.
Unfortunately the movie Mighty Mouse in the Great Space Chase is not yet available on HBO Max.
| Writing | Sam Simon | Writer |
| Writing | Buzz Dixon | Writer |
| Visual Effects | Milton Gray | Animation |
| Production | Don Christensen | Producer |
| Directing | Ed Friedman | Director |
| Directing | Lou Kachivas | Director |
| Directing | Marsh Lamore | Director |
| Directing | Gwen Wetzler | Director |
| Directing | Kay Wright | Director |
| Directing | Louis Zukor | Director |
| Production | Norm Prescott | Producer |
| Production | Lou Scheimer | Producer |
| Sound | Ray Ellis | Music |
| Sound | Norm Prescott | Music |
| Crew | R.W. Pope | Cinematography |
| Editing | Earl Biddle | Editor |
| Editing | Jim Blodgett | Editor |
| Editing | Ann Hagerman | Editor |