Shorts from "The New Adventures of Mighty Mouse and Heckle and Jeckle" Saturday morning cartoon show edited together into a movie. Space cat villain Harry the Heartless holds space mouse Queen Pureheart. Only Mighty Mouse can save her.
Unfortunately the movie Mighty Mouse in the Great Space Chase is not yet available on HBO Max.
| Writing | Buzz Dixon | Writer |
| Writing | Sam Simon | Writer |
| Visual Effects | Milton Gray | Animation |
| Production | Don Christensen | Producer |
| Directing | Kay Wright | Director |
| Directing | Ed Friedman | Director |
| Sound | Norm Prescott | Music |
| Editing | Earl Biddle | Editor |
| Production | Lou Scheimer | Producer |
| Editing | Ann Hagerman | Editor |
| Editing | Jim Blodgett | Editor |
| Sound | Ray Ellis | Music |
| Directing | Louis Zukor | Director |
| Crew | R.W. Pope | Cinematography |
| Production | Norm Prescott | Producer |
| Directing | Marsh Lamore | Director |
| Directing | Lou Kachivas | Director |
| Directing | Gwen Wetzler | Director |