Portland, Oregon, 1971. Bob Hughes is the charismatic leader of a peculiar quartet, formed by his wife, Dianne, and another couple, Rick and Nadine, who skillfully steal from drugstores and hospital medicine cabinets in order to appease their insatiable need for drugs. But neither fun nor luck last forever.
Unfortunately the movie Drugstore Cowboy is not yet available on HBO Max.
| Production | Nick Wechsler | Producer |
| Art | David Brisbin | Production Design |
| Production | Cary Brokaw | Executive Producer |
| Writing | Gus Van Sant | Screenplay |
| Directing | Gus Van Sant | Director |
| Camera | Robert D. Yeoman | Director of Photography |
| Production | Sharon Bialy | Casting |
| Production | Karen Murphy | Producer |
| Art | Eve Cauley | Art Direction |
| Art | Margaret Goldsmith | Set Decoration |
| Writing | Daniel Yost | Screenplay |
| Editing | Mary Bauer | Editor |
| Sound | Elliot Goldenthal | Original Music Composer |
| Production | Richard Pagano | Casting |
| Production | Karen Koch | Production Manager |
| Directing | David B. Householter | First Assistant Director |
| Directing | Robin Leigh Fleck | Second Assistant Director |
| Production | Eric McLeod | Production Coordinator |
| Production | Claudia Lewis | Production Executive |
| Art | Michael Gastaldo | Property Master |
| Production | Laurie Parker | Production Executive |
| Art | Missy Stewart | Set Dresser |
| Lighting | Chris Morley | Gaffer |
| Costume & Make-Up | Lizbeth Williamson | Makeup Artist |
| Sound | Ron Judkins | Sound Mixer |
| Sound | Robert Jackson | Boom Operator |
| Costume & Make-Up | Marsha Perloff | Wardrobe Supervisor |
| Production | Charles Harrington | Location Manager |
| Camera | Les Percy | Key Grip |
| Camera | Eric Alan Edwards | Second Unit Director of Photography |
| Costume & Make-Up | Gina Monaci | Hair Designer |
| Sound | Joel Iwataki | Sound Engineer |
| Sound | Dane A. Davis | Supervising Sound Editor |
| Crew | David Boushey | Stunt Coordinator |
| Sound | Joan Rowe | Foley Artist |
| Sound | Wayne Heitman | Sound Re-Recording Mixer |
| Costume & Make-Up | Beatrix Aruna Pasztor | Costume Designer |
| Crew | Leslie A. Leitner | Post Production Supervisor |
| Sound | Jerry Trent | Foley Artist |
| Sound | Mark 'Frito' Long | Sound Recordist |
| Editing | Curtiss Clayton | Editor |
| Sound | Matthew Iadarola | Sound Re-Recording Mixer |
| Directing | Jane Goldsmith | Script Supervisor |
| Sound | John Kwiatkowski | Sound Effects Editor |
| Writing | James Fogle | Novel |
