In Columbo's first outing, a psychiatrist uses a patient he is having an affair with to help him kill his wife, but his perfect alibi may come apart at the hands of a seemingly befuddled LAPD lieutenant.
Unfortunately the movie Prescription: Murder is not yet available on HBO Max.
| Sound | Dave Grusin | Original Music Composer |
| Art | James Redd | Set Decoration |
| Writing | Richard Levinson | Teleplay |
| Production | Richard Irving | Producer |
| Art | John McCarthy Jr. | Set Decoration |
| Costume & Make-Up | Bud Westmore | Makeup Artist |
| Writing | William Link | Teleplay |
| Art | Russell Kimball | Art Direction |
| Visual Effects | Robert Brower | Color Designer |
| Directing | Richard Irving | Director |
| Camera | Ray Rennahan | Director of Photography |
| Production | Jerrold Freedman | Associate Producer |
| Production | Edward K. Dodds | Unit Manager |
| Sound | James T. Porter | Sound |
| Costume & Make-Up | Larry Germain | Hairstylist |
| Costume & Make-Up | Burton Miller | Costume Designer |
| Editing | Richard Belding | Supervising Editor |
| Directing | George Bisk | Assistant Director |
| Sound | Stanley Wilson | Music Supervisor |
| Editing | Richard G. Wray | Editor |
