A letter from Jane, who is nursing British troops, asks Tarzan's help in obtaining a malaria serum extractable from jungle plants. Tarzan and Boy set out across the desert looking for the plants. Along the way they befriend a stranded American lady magician.
Unfortunately the movie Tarzan's Desert Mystery is not yet available on HBO Max.
| Directing | Wilhelm Thiele | Director |
| Writing | Edgar Rice Burroughs | Characters |
| Writing | Edward T. Lowe Jr. | Writer |
| Writing | Carroll Young | Story |
| Production | Sol Lesser | Producer |
| Production | Kurt Neumann | Associate Producer |
| Sound | Paul Sawtell | Music |
| Camera | Russell Harlan | Director of Photography |
| Camera | Harry J. Wild | Director of Photography |
| Editing | Ray H. Lockert | Editor |
| Art | Ralph Berger | Art Direction |
| Art | Hans Peters | Art Direction |
| Art | Victor A. Gangelin | Interior Designer |
| Art | Stanley Murphy | Interior Designer |
| Directing | Derwin Abrahams | Assistant Director |
| Sound | Bailey Fesler | Sound Technical Supervisor |
| Sound | Jean L. Speak | Sound Technical Supervisor |
| Costume & Make-Up | Elmer Ellsworth | Wardrobe Designer |
| Sound | C. Bakaleinikoff | Music Director |
| Crew | Sol Lesser | Presenter |
