A fanatical animal rights activist releases giant pythons into the Everglades, believing the wild animals should be set free. When they start decimating the native animal population, an over-zealous park ranger feeds experimental steroids to wild alligators so they can fight back. The giant pythons and gargantuan alligators go on a killing spree, and it is now left up to the two feuding women to put aside their differences to put a stop to the creatures and the destruction.
Unfortunately the movie Mega Python vs. Gatoroid is not yet available on HBO Max.
| Directing | Mary Lambert | Director |
| Lighting | Brendon Phillips | Gaffer |
| Crew | Tony Snegoff | Stunts |
| Crew | Laurence Todd Rosenthal | Stunts |
| Crew | Cole S. McKay | Utility Stunts |
| Crew | Mam Smith | Stunt Double |
| Crew | Chris Papajohn | Utility Stunts |
| Visual Effects | Sasha Burrow | VFX Artist |
| Production | Christopher Ray | Line Producer |
| Production | Debbie Gibson | Co-Producer |
| Production | David L. Garber | Associate Producer |
| Production | Paul Bales | Co-Producer |
| Camera | Troy Smith | Director of Photography |
| Costume & Make-Up | Teri Groves | Key Makeup Artist |
| Camera | Alexander Yellen | Camera Operator |
| Production | Michael C. Parisi | Location Manager |
| Visual Effects | Mark Kochinski | Visual Effects Supervisor |
| Art | Aaron Bautista | Art Direction |
| Costume & Make-Up | Reneé Parry | Assistant Makeup Artist |
| Crew | Mark Quod | Post Production Supervisor |
| Crew | Sean Christopher | Stunts |
| Camera | Conner Vandeer | Steadicam Operator |
| Art | Niko Vilaivongs | Production Design |
| Sound | Brett Bach | Supervising Sound Editor |
| Sound | Craig Polding | Sound Re-Recording Mixer |
| Camera | Alexander Yellen | Second Unit Director of Photography |
| Directing | Carlos Reza | Second Assistant Director |
| Costume & Make-Up | Katie Machaiek | Assistant Makeup Artist |
| Directing | Thomas Kuk | First Assistant Director |
| Sound | Brett Bach | Sound Re-Recording Mixer |
| Sound | Matt Schwartz | Sound Effects Editor |
| Crew | Spice Williams-Crosby | Stunt Double |
| Art | Jocelyn Collins | Property Master |
| Visual Effects | Emanuel Rosario | VFX Artist |
| Production | Catherine Ames | Production Assistant |
| Production | Thomas P. Vitale | Executive Producer |
| Visual Effects | Joseph J. Lawson | Visual Effects Supervisor |
| Editing | Mark Quod | Colorist |
| Production | David Michael Latt | Producer |
| Production | Karen O'Hara | Associate Producer |
| Production | Scotty Atkins | Associate Producer |
| Editing | Shawn David Thompson | Editor |
| Costume & Make-Up | Michelle Matteo | Costume Design |
| Directing | Suzanne C. Swindle | Script Supervisor |
| Production | Ray Cannella | Associate Producer |
| Production | David Rimawi | Executive Producer |
| Production | Tiffany | Co-Producer |
| Production | Thomas Kuk | Unit Production Manager |
| Production | Glenn Miller | Casting |
| Crew | Karin Justman | Stunt Double |
| Sound | Fred Paragano | ADR Mixer |
| Crew | Steve Hart | Stunt Coordinator |
| Camera | Calvin Cairns | Still Photographer |
| Production | Mary E. Brown | Production Supervisor |
| Sound | Lisa Ries | Sound Editor |
| Visual Effects | Aaron Witlin | VFX Artist |
| Costume & Make-Up | Laura Peyer | Costumer |
| Costume & Make-Up | Jason Griffin | Assistant Costume Designer |
| Sound | Thomas Corkran | Sound Mixer |
| Sound | Brian Calhoon | ADR Recordist |
| Crew | Ashley Carr | Post Production Assistant |
| Production | Ashley Carr | Casting Assistant |
| Sound | Chris Ridenhour | Original Music Composer |
| Writing | Naomi L. Selfman | Writer |
