A fire in the mountains drives a wolf pack into the nearby desert where they terrorize the local residents. The leader of the wolf pack is Lobo, actually a halfbreed (Rin Tin Tin). When the pack is discovered hunting a herd of cows, a posse gives chase. Lobo leaves his pack to lead the posse away. He is injured and found by a local prospector, Dave Weston (Charles Farrell). The prospector nurses Lobo back to health and the two become close friends. Meanwhile, Weston has made a Borax find in the area. His girlfriend May Barstowe (June Marlowe), daughter of a wealthy rancher, is pleased. However, the local chemist, Borax Horton (Pat Hartigan), actually a claim jumper, plans to steal the claim.
Unfortunately the movie Clash of the Wolves is not yet available on HBO Max.
| Directing | Noel M. Smith | Director |
| Art | Lewis Geib | Art Direction |
| Editing | Clarence Kolster | Editor |
| Camera | Edwin B. DuPar | Director of Photography |
| Camera | Joseph Walker | Director of Photography |
| Camera | Allen Q. Thompson | Director of Photography |
| Art | Esdras Hartley | Art Direction |
| Writing | Charles Logue | Writer |
