A fading celebrity decides to use a black market drug, a cell-replicating substance that temporarily creates a younger, better version of herself.
Unfortunately the movie The Substance is not yet available on HBO Max.
| Directing | Matthieu de la Mortière | First Assistant Director |
| Directing | Anne Juin | Third Assistant Director |
| Production | Erik Baiers | Executive Producer |
| Art | Stanislas Reydellet | Production Design |
| Camera | Benjamin Kračun | Director of Photography |
| Editing | Jérôme Eltabet | Editor |
| Art | Cécilia Blom | Set Decoration |
| Costume & Make-Up | Frédérique Arguello | Hair Department Head |
| Costume & Make-Up | Frédéric Balmer | Special Effects Makeup Artist |
| Costume & Make-Up | Denise Boccacci | Prosthetic Makeup Artist |
| Costume & Make-Up | Andrea Leanza | Prosthetics Sculptor |
| Art | Sebastian Lochmann | Concept Artist |
| Costume & Make-Up | Richard Martin | Prosthetics Sculptor |
| Art | Krystell Morantin | Assistant Art Director |
| Visual Effects | Bryan Jones | Visual Effects Supervisor |
| Crew | Marie Bouvet | Stunt Double |
| Crew | Jérôme Gaspard | Stunt Coordinator |
| Crew | Guillemette Buffet | Stunt Double |
| Crew | Ahmed Chouikhi | Stunts |
| Crew | Joffrey Darel | Stunt Driver |
| Crew | Jérémie Delaboudinière | Stunts |
| Crew | Arthur Delapierre | Stunts |
| Crew | Stephane Girondeaud | Stunts |
| Crew | Lucile Perez | Stunts |
| Crew | Céline Richard | Stunts |
| Crew | Marie Sergeant | Stunts |
| Camera | Chloè Acher | Second Assistant Camera |
| Lighting | Edouard Alvernhe | Electrician |
| Camera | Vianne Burquier | Camera Intern |
| Camera | Laure Caniaux | First Assistant Camera |
| Camera | Benjamin Colleye | Additional First Assistant Camera |
| Camera | Marie-Sophie Daniel | First Assistant Camera |
| Camera | Steve de Rocco | Camera Operator |
| Lighting | Charles Droudun | Electrician |
| Crew | Yann Festinger | Video Assist Operator |
| Camera | Catherine Georges | Camera Operator |
| Camera | Tanguy Goasguen | Additional Grip |
| Camera | Thomas Gros | Key Grip |
| Camera | Gustin Guillaume | First Assistant Camera |
| Lighting | Guillaume Lemerle | Gaffer |
| Camera | Stella Libert | First Assistant Camera |
| Lighting | Nahi Margot | Electrician |
| Camera | Baptiste Marnière | Digital Imaging Technician |
| Lighting | Olivier Maurin | Electrician |
| Camera | Jonas Poignant | Third Assistant Camera |
| Camera | William Renaud | Grip |
| Lighting | Olivier Sargatal | Best Boy Electric |
| Camera | Christine Tamalet | Still Photographer |
| Camera | Ludovic Tobaldi | Steadicam Operator |
| Camera | Eddy Trouillot | Grip |
| Costume & Make-Up | Camille Damag | Costume Supervisor |
| Costume & Make-Up | Fabienne Menguy | Costume Supervisor |
| Production | Noémie Lance | Location Manager |
| Art | Nadege Marti | Location Scout |
| Production | Katia Sourzac | Location Production Assistant |
| Production | Baptiste Herment | Production Accountant |
| Editing | Fabien Pascal | Colorist |
| Editing | Benjamin Durfort | Assistant Editor |
| Art | Baptiste Bonin | Props |
| Art | Benjamin Bouygues-Faugeron | Property Buyer |
| Directing | Coralie Fargeat | Director |
| Production | Coralie Fargeat | Producer |
| Production | Eric Fellner | Producer |
| Production | Tim Bevan | Producer |
| Production | Alexandra Loewy | Executive Producer |
| Production | Nicolas Royer | Executive Producer |
| Sound | Raffertie | Original Music Composer |
| Costume & Make-Up | Olivier Afonso | Special Effects Makeup Artist |
| Costume & Make-Up | Jean-Marc Benois | Key Hair Stylist |
| Costume & Make-Up | Oriane Cattiaux | Makeup Artist |
| Costume & Make-Up | Marison De | Special Effects Makeup Artist |
| Costume & Make-Up | Sandrine Denis | Special Effects Makeup Artist |
| Costume & Make-Up | Dave Elsey | Prosthetic Supervisor |
| Costume & Make-Up | Lou Elsey | Prosthetic Supervisor |
| Costume & Make-Up | Stéphanie Guillon | Key Makeup Artist |
| Costume & Make-Up | Mélissa Jacob | Additional Hairstylist |
| Costume & Make-Up | Brian Kinney | Special Effects Makeup Artist |
| Costume & Make-Up | Lucky Nguyen | Makeup Artist |
| Costume & Make-Up | Bryony Rumble | Special Effects Makeup Artist |
| Costume & Make-Up | Marilyne Scarselli | Hair Supervisor |
| Costume & Make-Up | Cynthia Scigliuto | Makeup Artist |
| Costume & Make-Up | Caroline Vlieghe | Hairstylist |
| Production | Julia Besnier | Production Accountant |
| Production | Benjamin Celliez | Unit Production Manager |
| Production | Pierre-Yves Frohard | Production Coordinator |
| Crew | Abraham Goldblat | Post Production Supervisor |
| Crew | Tiva Nagchin | Post Production Supervisor |
| Production | Honorine Sutter | Assistant Production Manager |
| Directing | Clément Audebrand | Third Assistant Director |
| Directing | Mateo Cejoco | Third Assistant Director |
| Directing | Louis Tellier | Third Assistant Director |
| Directing | Benoit Seiller | Second Assistant Director |
| Crew | Louis Celnik | Carpenter |
| Art | Marion Didier | Assistant Art Director |
| Art | Elise Duvignau | Props |
| Art | Barthelemy Thomas | Set Dresser |
| Art | Amélie Meseguer | Assistant Set Decoration |
| Editing | Coralie Fargeat | Editor |
| Art | Marjane Texier | Graphic Designer |
| Art | Elsa Rolland | Assistant Property Master |
| Art | Chloé Zobel | Property Master |
| Visual Effects | Jean Miel | Special Effects Supervisor |
| Crew | Olaf Taittinger | Special Effects |
| Visual Effects | Louis Auger | Digital Compositor |
| Visual Effects | Téo L'Huillier | Digital Compositor |
| Visual Effects | Guillaume Le Gouez | Visual Effects Supervisor |
| Visual Effects | Louis Lion | Digital Compositor |
| Visual Effects | Jacob Rogers | Digital Compositor |
| Camera | Guillaume Billy | Camera Trainee |
| Camera | Christophe Arnaud | Additional Second Assistant Camera |
| Camera | Thomas Burgess | Steadicam Operator |
| Production | Jacques-Emmanuel Astor | Extras Casting |
| Production | Raphaëlle Beck | Extras Casting |
| Production | Aurélie Boutet | Casting Assistant |
| Costume & Make-Up | Elsa Manunta | Set Costumer |
| Editing | Jimmy Zhao | First Assistant Editor |
| Production | Isalys Gillet | Location Assistant |
| Production | Steve Sebir | Assistant Location Manager |
| Production | Christophe Riso | Assistant Location Manager |
| Sound | Guillaume Baurez | Music Supervisor |
| Directing | Marianne Huet | Script Supervisor |
| Editing | Valentin Féron | Editor |
| Costume & Make-Up | Pierre Olivier Persin | Prosthetics |
| Costume & Make-Up | Pierre Olivier Persin | Makeup Effects Designer |
| Art | Marion De Villechabrolle | Set Decoration |
| Art | Stéphane Bécimol | Art Direction |
| Art | Arnaud Denis | Art Direction |
| Art | Gladys Garot | Art Direction |
| Art | Amélie Meseguer | Art Direction |
| Art | Julie Plumelle | Art Direction |
| Art | Nathalie Vaïsse | Art Direction |
| Costume & Make-Up | Emmanuelle Youchnovski | Costume Designer |
| Sound | Claire Bernengo | Boom Operator |
| Sound | Patrick Christensen | ADR Mixer |
| Sound | Valérie Deloof | Sound Editor |
| Sound | Valérie Deloof | Sound Designer |
| Sound | Anna Devillaire | ADR Editor |
| Sound | Victor Fleurant | Sound Editor |
| Sound | Judah Getz | ADR Mixer |
| Sound | Olga Pasternak | Supervising Dialogue Editor |
| Sound | Margaux Peyre | Boom Operator |
| Sound | Thomas Pichon | Dialogue Editor |
| Sound | Victor Praud | Sound Re-Recording Mixer |
| Sound | Lucien Richardson | Supervising Dialogue Editor |
| Sound | Antoine Swertvaegher | Foley Editor |
| Sound | Stéphane Thiébaut | Sound Re-Recording Mixer |
| Sound | Emmanuelle Villard | Sound Mixer |
| Sound | Grégory Vincent | Foley Artist |
| Writing | Coralie Fargeat | Writer |
| Production | Laure Cochener | Casting |
