A boy and his grandfather are exposed to a shrink gas and come face-to-face with the grandfather's insect creations. Pint-sized, they try to stop an evil Queen and face other adventures.
Two creatures, one named "Something", the other named "Something Else" try to co-exist peacefully despite the fact that they are complete opposites. Imagine The Odd Couple as if it were done by Dr. Suess and you've got the basic idea.