The further adventures of Wang Wuji, Liu Xian'er, and Drunken Babe, after the defeat of Lian Bixie and Little Sword Immortal in the previous series. New threats arise in the form of two rivaling evil sect leaders, the Sun Emperor and the Moon Empress.
Wang Wuji, Liu Xian'er and Drunken Babe accidentally got involved in the struggles between them. Xian'er was even killed by the Moon Queen. Wuji cooperated with the Sun Emperor for revenge, but was betrayed by him. Later, the Sun Emperor and Moon Empress settled their differences. The two mastered supreme kung-fu and wanted to dominate the world. Wuji and the others decided to fight to prevent the catastrophe in the martial arts world.
Yang Yanzhao was betrayed by Pang Long and died in battle. Yanzhao's son Yang Zongbao confronted Pang Long Gongtang, and the two insisted on each other, and Yin Bao Zheng of Kaifeng Prefecture designed to have Pang Long personally write down the crime, and Pang Long was sentenced to dragon head ginseng. The bereaved Taishi Pang Xiong swore to kill Bao Zheng and the Yang family general, and the Yang family would join Bao Zheng to fight against Pang Taishi...
Lee Ting-hong joins Guangji Hospital, where he meets the chairwoman's daughter, Xue Baoqi. They initially misunderstand each other but eventually become a couple. As they witness patients, and even acquaintances, die mysteriously, they investigate and discover that the events are related to the hospital's director, Tang Zhiyang, and the chief surgeon, Guo Weicheng.
After a long period of peace, the Western Xia dynasty invades the Song dynasty, leading to the deaths of Yang Liu Lang and Yang Zong Bao at the hands of Pang Tai Shi. Mu Guiying attempts to lead the female warriors of the Yang family into battle, but is falsely accused and faces many obstacles, including being separated from Yang Pai Feng, who later encounters an amnesiac Yelü Haonan and develops feelings for him.
Li Yuanhao, the prince of Western Xia, secretly approaches Guiying and others to deceive them and attempts to use their help to seize the throne. In the end, his scheme is exposed, and he is saved by the Bǎihuā Princess. Guiying is appointed as the commander to fight against Western Xia, but Yuanhao kidnaps Pai Feng and forces Haonan to help him kill his father and seize the throne, as well as to fight against the Song army. Guiying vows to eliminate Yuanhao.