The fate of mankind is doomed in the early 21st century due to losing "purana," an essence of living force supporting all life forms. Not willing to witness the extinction of mankind, a vampire named Duo disclosed the secret of purana to humans, saving the latter from destruction. However, just like Prometheus in Greek mythology got punished for bringing fire to mankind, Duo is punished for breaking the taboo. The vampire sent to punish him is Zieg, Duo's best friend, or, more than the best friend.
The story revolves around Nekoyama Suzu, a timid, shy tsundere girl loves dogs, and Inugami Yachiyo, a super masochistic, air-headed, friendly girl who loves cats. One day, after a fateful meeting, the two find themselves attracted to each other. In response to Inugami's instinctive approaches, Nekoyama is always bashful. Their friend Aki has to work hard to make jabs at some of the situations of the two, and also to stop Inugami from going berserk.