Two-time Emmy Award-winner Megan Mullally, coming off eight seasons as wisecracking socialite Karen Walker on NBC's "Will & Grace," moves into the driver's seat as host for this daytime talk show. Each episode is an entertaining hour featuring a mix of celebrities, real people, music, and comedy. Megan will interview top celebrities and also introduce the world to guests of all kinds — from quirky characters to funny kids to offbeat experts.
| Title | Air Date | Duration | ||
|---|---|---|---|---|
| Season 1 | Episode 1 | Will Ferrell, Jenny McCarthy | 2006-09-18 | 60 min |
| Season 1 | Episode 2 | Eva Mendes, "So You Think You Can Dance", Granny Basketball | 2006-09-19 | 60 min |
| Season 1 | Episode 3 | Lisa Kudrow, 10 year-old Opera Singer, Adam Rodriguez | 2006-09-20 | 60 min |
| Season 1 | Episode 4 | Carol Burnett, Rainn Wilson, Hollerin' Championships | 2006-09-21 | 60 min |
| Season 1 | Episode 5 | Felicity Huffman, 'Animal Guys' Paul Hahn and David Riherd, Enrique Murciano | 2006-09-22 | 60 min |
| Season 1 | Episode 6 | Julia Louis-Dreyfus, Illusionist Criss Angel, Mario Lopez | 2006-09-25 | 60 min |
| Season 1 | Episode 7 | Debra Messing, Fashion Makeover with Lucky Magazine, Omar Epps | 2006-09-26 | 60 min |
| Season 1 | Episode 8 | George Lopez, Jennifer Finnigan, Vacuum Cleaning Genius, Tim Bagley At A Cher Convention | 2006-09-27 | 60 min |
| Season 1 | Episode 9 | Sela Ward, Chris Noth | 2006-09-28 | 60 min |
| Season 1 | Episode 10 | Patricia Heaton, Duane Martin, Jesse McCartney | 2006-09-29 | 60 min |
| Season 1 | Episode 11 | Jane Kaczmarek, Masi Oka, Champion Cloggers | 2006-10-02 | 60 min |
| Season 1 | Episode 12 | Tom Bergeron, Eric Stromer, Elizabeth Perkins | 2006-10-03 | 60 min |
| Season 1 | Episode 13 | Tim Daly, Domino Magazine | 2006-10-04 | 60 min |
| Season 1 | Episode 14 | Connie Britton, Michael Clark Duncan | 2006-10-05 | 60 min |
| Season 1 | Episode 15 | Jennifer Love Hewiitt, Jonny Lee Miller, J. Xavier | 2006-10-06 | 60 min |
| Season 1 | Episode 16 | Virginia Madsen, Noah Gray-Cabey, Around The Office | 2006-10-09 | 60 min |
| Season 1 | Episode 17 | Marcia Cross, Clinton Kelly, Isaiah Washington | 2006-10-10 | 60 min |
| Season 1 | Episode 18 | Molly Ringwald, OK Go | 2006-10-11 | 60 min |
| Season 1 | Episode 19 | Wanda Sykes, Goran Visnjic, Ruben Studdard | 2006-10-12 | 60 min |
| Season 1 | Episode 20 | Peter Gallagher, Nathan Burton, Tyler James Williams | 2006-10-13 | 60 min |
| Season 1 | Episode 21 | Bradley Whitford, Shelley Morrison, Eric Mabius, Mario Vazquez, Phil Pfister | 2006-10-16 | 60 min |
| Season 1 | Episode 22 | Cheyenne Kimball, Laura Linney, Ricardo Antonio Chavira | 2006-10-17 | 60 min |
| Season 1 | Episode 23 | Merv Griffin, Kim Raver, Author Jennifer Egan | 2006-10-18 | 60 min |
| Season 1 | Episode 24 | Rob Morrow, Rebecca Cole, Anne Heche, Joshua Bell | 2006-10-19 | 60 min |
| Season 1 | Episode 25 | Josh Duhamel, Alison Lohman, Authors Mark Leyner and Bill Goldberg, Aly & AJ Michalka | 2006-10-20 | 60 min |
| Season 1 | Episode 26 | Kristin Chenoweth, Jill Conner Browne, Nick & Aaron Carter, the Sweet Potato Queens | 2006-10-23 | 60 min |
| Season 1 | Episode 27 | Jamie Lee Curtis, The Mystic Pixies, Amy Smart, Taylor Swift | 2006-10-24 | 60 min |
| Season 1 | Episode 28 | Lauren Holly, Ruben Studdard, Daniel Dae Kim | 2006-10-25 | 60 min |
| Season 1 | Episode 29 | Cloris Leachman, Jensen Ackles, Dog Halloween Costumes with Teri Austin, ecostylist Danny Seo | 2006-10-26 | 60 min |
| Season 1 | Episode 30 | James Denton, Yahoo 9's Maria Sansone, Angela Kinsey, JoJo | 2006-10-27 | 60 min |
| Season 1 | Episode 31 | Steven Weber, Audra McDonald | 2006-10-30 | 60 min |
| Season 1 | Episode 32 | Neil Patrick Harris, Kevin Federline | 2006-10-31 | 60 min |
| Season 1 | Episode 33 | Jamie Kennedy, Jeffrey Sebelia, Meat Loaf, Card Thrower Rick Smith | 2006-11-01 | 60 min |
| Season 1 | Episode 34 | Clay Aiken, Tysonia Tschinga "real life" Dancing with the Stars | 2006-11-02 | 60 min |
| Season 1 | Episode 35 | Sean Hayes, Eddie Cibrian, Dog Whisperer Cesar Millan, Author Mitch Albom | 2006-11-03 | 60 min |
| Season 1 | Episode 36 | Barry Manilow, Parminder Nagra, Tim Bagley visits "America's Got Talent", Kid's Ballroom Dancing | 2006-11-06 | 60 min |
| Season 1 | Episode 37 | Mark Harmon, Hip Hop Champions, Constance Zimmer, Melora Hardin | 2006-11-07 | 60 min |
| Season 1 | Episode 38 | Kevin Nealon, Antonio Sabato Jr. | 2006-11-08 | 60 min |
| Season 1 | Episode 39 | Bob Saget, sex educator Sue Johanson | 2006-11-09 | 60 min |
| Season 1 | Episode 40 | Molly Sims, Andrea Bowen, The Ten Tenors, Celebrity trainer Michael Carson | 2006-11-10 | 60 min |
| Season 1 | Episode 41 | Cheryl Hines, Tim Gunn, Thanksgiving Dog Adoption Fashion Show | 2006-11-13 | 60 min |
| Season 1 | Episode 42 | David Hyde Pierce, Linda Cardellini, Taylor Ware | 2006-11-14 | 60 min |
| Season 1 | Episode 43 | Patricia Arquette, Champion Pirouette Dancer, Daily Candy Trends | 2006-11-15 | 60 min |
| Season 1 | Episode 44 | Dax Shepard, Tom Arnold, Kimberley Locke | 2006-11-16 | 60 min |
| Season 1 | Episode 45 | Reba McEntire, Patrick Wilson, RBD | 2006-11-17 | 60 min |
| Season 1 | Episode 46 | Tom Bergeron, Trista and Ryan, Benji Schwimmer, Rupert Boneham | 2006-11-20 | 60 min |
| Season 1 | Episode 47 | Sharon Stone, Scott Foley, Rusty Schwimmer, Paz Vega, Danny Seo | 2006-11-21 | 60 min |
| Season 1 | Episode 48 | Wayne Brady, Penguins Pete and Penny, Nestle Toll House Bake Sale Finalist | 2006-11-22 | 60 min |
| Season 1 | Episode 49 | Camryn Manheim, Phil Pfister, James Lesure, Author Karen Rizzo | 2006-11-24 | 60 min |
| Season 1 | Episode 50 | Neil Patrick Harris, Josh Radnor, Alyson Hannigan, Jason Segel and Cobie Smulders | 2006-11-27 | 60 min |
| Season 1 | Episode 51 | David Boreanaz, Julianne Nicholson, Bianca Ryan | 2006-11-28 | 60 min |
| Season 1 | Episode 52 | Matthew Broderick, Donald Faison, Brian Baumgartner, the Bucket Boys, Catherine Lloyd Burns | 2006-11-29 | 60 min |
| Season 1 | Episode 53 | Tracy Morgan, Melissa Peterman, Jarod Miller, Eric Stromer | 2006-11-30 | 60 min |
| Season 1 | Episode 54 | Carrie Fisher, Paul Rodriguez, Nadine Velazquez | 2006-12-01 | 60 min |
| Season 1 | Episode 55 | Rosanna Arquette, Tom Green, Adrian Pasdar | 2006-12-04 | 60 min |
| Season 1 | Episode 56 | Marla Sokoloff, Taylor Hicks, "Campus Ladies" | 2006-12-05 | 60 min |
| Season 1 | Episode 57 | Phyllis Diller | 2006-12-06 | 60 min |
| Season 1 | Episode 58 | Carson Kressley, Beau Bridges, Amy Sedaris | 2006-12-07 | 60 min |
| Season 1 | Episode 59 | Wendie Malick, Janice Dickinson | 2006-12-08 | 60 min |
| Season 1 | Episode 60 | John Stamos, Brenda Strong, Cris Judd, Tyrese | 2006-12-11 | 60 min |
| Season 1 | Episode 61 | David James Elliott, Michael Ealy, Lisa Edelstein, magician Nathan Burton | 2006-12-12 | 60 min |
| Season 1 | Episode 62 | Jeffrey Tambor, Tisha Campbell, designer Mark Montano, Hall & Oates | 2006-12-13 | 60 min |
| Season 1 | Episode 63 | Shawn and Marlon Wayans, Taylor Hicks | 2006-12-14 | 60 min |
| Season 1 | Episode 64 | Oded Fehr, Rob Morrow, Rhea Perlman, Sarah Rush | 2006-12-15 | 60 min |
| Season 1 | Episode 65 | Howie Mandel, Jennie Garth, Ahmet Zappa, psychic medium Lisa Williams | 2006-12-18 | 60 min |
| Season 1 | Episode 66 | Jane Seymour, David Conrad, Ken Davitian, Joshua Radin | 2006-12-19 | 60 min |
| Season 1 | Episode 67 | Alfre Woodard, Milo Ventimiglia, Fantasia Barrino | 2006-12-20 | 60 min |
| Season 1 | Episode 68 | Billy Ray Cyrus, Richard Simmons, authors of "Party Confidential" | 2006-12-21 | 60 min |
| Season 1 | Episode 69 | Hall & Oates, Brian McKnight, Clay Aiken, José Feliciano, Kimberley Locke, Celtic Woman | 2006-12-22 | 60 min |
| Season 1 | Episode 70 | Emily Procter, Tichina Arnold, Goo Goo Dolls | 2007-01-08 | 60 min |
| Season 1 | Episode 71 | Natalie Cole, Craig Bierko, Dave Annable, Blaine Zuckerman | 2007-01-09 | 60 min |
| Season 1 | Episode 72 | Tom Bergeron, Tim Daly, Will Ferrell, Allison Janney, Davy Jones, Chris Noth, Jerry Springer | 2007-01-15 | 60 min |
| Season 1 | Episode 73 | Patricia Heaton, Cheryl Hines, Debra Messing, Christine Taylor | 2007-01-16 | 60 min |
| Season 1 | Episode 74 | Josh Duhamel, Jamie Kennedy, George Lopez, Mario Lopez | 2007-01-17 | 60 min |
| Season 1 | Episode 75 | Selma Blair, Kristin Chenoweth, Lisa Kudrow, Laura Linney, Julia Louis-Dreyfus | 2007-01-18 | 60 min |
| Season 1 | Episode 76 | Chandra Wilson, Jesse Bradford, Clay Aiken | 2007-01-24 | 60 min |
