Professor Utonium and his son Ken are studying the strange Chemical X. When a mochi cake falls into the formula, it changes into Chemical Z. Ken fires a ray of Chemical Z at a glacier in Tokyo Bay, however that causes strange lights to scatter, some of them aim at three normal girls, Momoko, Miyako, and Kaoru. This gives them the power to transform into superheroes, the Powerpuff Girls Z!
| Title | Air Date | Duration | ||
|---|---|---|---|---|
| Season 1 | Episode 1 | Powerpuff Girls to the Rescue / The Secret of the Powerpuff Girls | 2006-07-01 | 24 min |
| Season 1 | Episode 2 | Bouncing Bubbles | 2006-07-08 | 24 min |
| Season 1 | Episode 3 | And Then There Were Three | 2006-07-15 | 24 min |
| Season 1 | Episode 4 | All In the Family | 2006-07-22 | 24 min |
| Season 1 | Episode 5 | Mojo's Revenge / Climbing the Walls | 2006-07-29 | 24 min |
| Season 1 | Episode 6 | Fuzzy Lumpkins / Princess Morbucks | 2006-08-05 | 24 min |
| Season 1 | Episode 7 | Mayor for a Day / The Infamous Amoeba Boys | 2006-08-12 | 24 min |
| Season 1 | Episode 8 | Sedusa | 2006-08-19 | 24 min |
| Season 1 | Episode 9 | Coach Buttercup / Fuzzy in Love | 2006-08-26 | 24 min |
| Season 1 | Episode 10 | Gigi the Great | 2006-09-02 | 24 min |
| Season 1 | Episode 11 | Friends in High Places / Happy Birthday, New Townsville | 2006-09-09 | 24 min |
| Season 1 | Episode 12 | Bubbles' Troubles | 2006-09-16 | 24 min |
| Season 1 | Episode 13 | Mojo and the Amoeba Boys / Revenge of Negatron | 2006-09-23 | 24 min |
| Season 1 | Episode 14 | Attack of the Gangreen Gang | 2006-09-30 | 24 min |
| Season 1 | Episode 15 | Fashion Action / The Way of the Noodle | 2006-10-07 | 24 min |
| Season 1 | Episode 16 | Sleepless in New Townsville | 2006-10-14 | 24 min |
| Season 1 | Episode 17 | Picture This / Revenge of Digitron | 2006-10-21 | 24 min |
| Season 1 | Episode 18 | The Mojo League of Evil | 2006-10-28 | 24 min |
| Season 1 | Episode 19 | Practice Makes Pandemonium / Ms. Keane to the Rescue | 2006-11-04 | 24 min |
| Season 1 | Episode 20 | The Rowdyruff Boys | 2006-11-11 | 24 min |
| Season 1 | Episode 21 | Quack-Quack Attack / Veggie Vengeance | 2006-11-18 | 24 min |
| Season 1 | Episode 22 | Pastry Puff Panic | 2006-11-25 | 24 min |
| Season 1 | Episode 23 | A Comedy of Terrors / Beetle Battle | 2006-12-02 | 24 min |
| Season 1 | Episode 24 | A Ken in Need is a Friend Indeed | 2006-12-09 | 24 min |
| Season 1 | Episode 25 | The Write and the Wrong Way / Flower Power | 2006-12-16 | 24 min |
| Season 1 | Episode 26 | All Ken Wants for Christmas | 2006-12-23 | 24 min |
| Season 1 | Episode 27 | Attack of the Sushi Monsters / Cat On a Hot Tin Poochie | 2007-01-06 | 24 min |
| Season 1 | Episode 28 | The League of Lovely Ladies | 2007-01-13 | 24 min |
| Season 1 | Episode 29 | Harmed to the Teeth / Beware the Hair | 2007-01-20 | 24 min |
| Season 1 | Episode 30 | What's With Him? | 2007-01-27 | 24 min |
| Season 1 | Episode 31 | Dunga Din / The Beanie Meanie | 2007-02-03 | 24 min |
| Season 1 | Episode 32 | Two Burger-Bots and a Side of Fries | 2007-02-10 | 24 min |
| Season 1 | Episode 33 | There's no I in Powerpuff / Keane Kong | 2007-02-17 | 24 min |
| Season 1 | Episode 34 | Cleanliness is Next to Ghostliness | 2007-02-24 | 24 min |
| Season 1 | Episode 35 | Weeding out The Monsters / The Dog Days of New Townsville | 2007-03-03 | 24 min |
| Season 1 | Episode 36 | It's All Because of Him | 2007-03-10 | 24 min |
| Season 1 | Episode 37 | Super Tough Girls / Powerpuff Boys Z | 2007-03-17 | 24 min |
| Season 1 | Episode 38 | Enter the Entourage | 2007-03-24 | 24 min |
| Season 1 | Episode 39 | Little Ken's Big Wish / Wild Moon Chase | 2007-03-31 | 24 min |
| Season 1 | Episode 40 | Babes in TV Land / The Legend of Princess Morbucks | 2007-04-07 | 24 min |
| Season 1 | Episode 41 | The Mighty Morbucks / Trading Faces | 2007-04-14 | 24 min |
| Season 1 | Episode 42 | The Rowdyruff Girls | 2007-04-21 | 24 min |
| Season 1 | Episode 43 | The Professor Gets His Cut / Who is Lucas Clark? | 2007-04-28 | 24 min |
| Season 1 | Episode 44 | Buttercup's New Moves | 2007-05-05 | 24 min |
| Season 1 | Episode 45 | Hoppily Ever After / Vamp on Campus | 2007-05-12 | 24 min |
| Season 1 | Episode 46 | Return of Him | 2007-05-19 | 24 min |
| Season 1 | Episode 47 | Keane For a Break / Like Giving Candy to a Baby | 2007-05-26 | 24 min |
| Season 1 | Episode 48 | Bubbles and the Beast | 2007-06-02 | 24 min |
| Season 1 | Episode 49 | The Happy Thought Blaster / Nurse Curse | 2007-06-09 | 24 min |
| Season 1 | Episode 50 | Him's Big Plan | 2007-06-16 | 24 min |
| Season 1 | Episode 51 | Only a Matter of Time | 2007-06-23 | 24 min |
| Season 1 | Episode 52 | The Final Battle | 2007-06-30 | 24 min |
| Writing | Yoshio Urasawa | Series Composition |
| Directing | Iku Ishiguro | Series Director |
| Writing | Craig McCracken | Characters |
| Writing | Craig McCracken | Original Concept |
