Mystery Diagnosis is a television program that airs on the OWN: Oprah Winfrey Network. Each episode focuses on two or more individuals and their struggles to find out what ailments they suffer from. As the program's title suggests, doctors have a difficult time finding a diagnosis, often due to nonspecific symptoms, the rarity of the condition or disease, or the patient's case being an unusual manifestation of said condition or disease. The series debuted on Discovery Health Channel in 2005, and was continued when the Oprah Winfrey Network replaced Discovery Health on January 1, 2011; the current season premiered January 5, 2011.
| Title | Air Date | Duration | ||
|---|---|---|---|---|
| Season 1 | Episode 1 | Survivors | 2005-10-11 | 60 min |
| Season 1 | Episode 2 | Why is Emily Screaming? | 2005-10-14 | 60 min |
| Season 1 | Episode 3 | Issac's Nightmare | 2005-10-15 | 60 min |
| Season 1 | Episode 4 | Like Mother, Like Son | 2005-10-16 | 60 min |
| Season 1 | Episode 5 | Not a Normal Newborn | 2005-10-21 | 60 min |
| Season 1 | Episode 6 | Mystery Diagnosis | 2005-11-11 | 60 min |
| Season 1 | Episode 7 | Grasping for Straws | 2005-11-21 | 60 min |
| Season 1 | Episode 8 | Desperate for a Cure | 2005-11-28 | 60 min |
| Season 1 | Episode 9 | Blood Brothers | 2005-12-05 | 60 min |
| Season 2 | Episode 1 | A Puff of Smoke | 2006-01-09 | 60 min |
| Season 2 | Episode 2 | An Unquenchable Thirst | 2006-01-16 | 60 min |
| Season 2 | Episode 3 | Lethal Diet | 2006-01-23 | 60 min |
| Season 2 | Episode 4 | Falling Through the Cracks | 2006-03-06 | 60 min |
| Season 2 | Episode 5 | Eaten Alive | 2006-03-27 | 60 min |
| Season 2 | Episode 6 | The Man Who Never Sweats | 2006-04-03 | 60 min |
| Season 2 | Episode 7 | Fatal Secret | 2006-04-10 | 60 min |
| Season 2 | Episode 8 | The Stabbing Sensation | 2006-06-05 | 60 min |
| Season 2 | Episode 9 | The Man with Rocks in His Chest | 2006-06-12 | 60 min |
| Season 2 | Episode 10 | Implant for Tourettes | 2006-06-19 | 60 min |
| Season 3 | Episode 1 | Sleeping Beauty | 2007-04-09 | 60 min |
| Season 3 | Episode 2 | The Man Who Turned Orange | 2007-04-16 | 60 min |
| Season 3 | Episode 3 | Deadly Sore Throat | 2007-04-23 | 60 min |
| Season 3 | Episode 4 | The Man With Rocks in His Chest | 2007-05-14 | 60 min |
| Season 3 | Episode 5 | The 13 Year Stomach Ache | 2007-05-14 | 60 min |
| Season 3 | Episode 6 | The Bearded Lady | 2007-07-30 | 60 min |
| Season 3 | Episode 7 | The Boy Who Couldn't Breathe | 2007-08-20 | 60 min |
| Season 3 | Episode 8 | Frenetic Genetics | 2007-08-27 | 60 min |
| Season 3 | Episode 9 | The Baby Who Changed Colors | 2007-08-27 | 60 min |
| Season 3 | Episode 10 | Not a Normal Newborn | 2007-09-03 | 60 min |
| Season 4 | Episode 1 | The Girl Who Couldn't Eat | 2007-01-01 | 60 min |
| Season 4 | Episode 2 | Bizarre Visions | 2007-10-15 | 60 min |
| Season 4 | Episode 3 | The Woman Who Craved Pickles | 2007-10-22 | 60 min |
| Season 4 | Episode 4 | Donor Disaster | 2007-12-03 | 60 min |
| Season 4 | Episode 5 | The Purple Puzzle | 2007-12-10 | 60 min |
| Season 4 | Episode 6 | A Case of Paralysis | 2007-12-17 | 60 min |
| Season 4 | Episode 8 | The Purple Puzzle | 2007-12-10 | 60 min |
| Season 4 | Episode 9 | The Girl Nobody Believed | 2008-03-10 | 60 min |
| Season 4 | Episode 10 | The Woman Who Couldn't Cry | 2008-04-07 | 60 min |
| Season 4 | Episode 11 | The Woman with a Knife in Her Head | 2008-04-14 | 60 min |
| Season 4 | Episode 12 | Parents Pressing for Answers | 2008-04-21 | 60 min |
| Season 4 | Episode 13 | The Girl Who Gagged | 2008-04-28 | 60 min |
| Season 5 | Episode 1 | The Girl Who Couldn't Be Touched | 2008-01-14 | 60 min |
| Season 5 | Episode 2 | The Girl Who Gagged | 60 min | |
| Season 5 | Episode 3 | The Woman Who Kept Falling Down | 60 min | |
| Season 5 | Episode 4 | A Deadly Cough | 60 min | |
| Season 5 | Episode 5 | The Girl Nobody Believed | 60 min | |
| Season 5 | Episode 6 | The Headache That Wouldn't Go Away | 60 min | |
| Season 5 | Episode 7 | Terrifying Tremors | 60 min | |
| Season 5 | Episode 8 | The Woman Who Couldn't Cry | 60 min | |
| Season 5 | Episode 9 | The Woman with a Knife in Her Head | 60 min | |
| Season 6 | Episode 1 | The Woman with the Giant Lump | 2008-11-24 | 60 min |
| Season 6 | Episode 2 | The Woman Who Couldn't Stop Rocking | 2008-12-01 | 60 min |
| Season 6 | Episode 3 | The Baby Who Wouldn't Stop Crying | 2008-12-08 | 60 min |
| Season 6 | Episode 4 | The Girl Who Couldn't Wake Up | 2008-12-15 | 60 min |
| Season 6 | Episode 5 | The Girl Who Couldn't Move | 2009-03-02 | 60 min |
| Season 6 | Episode 6 | The Boy Who Kept Swelling | 2009-03-09 | 60 min |
| Season 6 | Episode 7 | The Boy Who Stopped Walking | 2009-03-16 | 60 min |
| Season 6 | Episode 8 | The Boy Who Bit Himself | 2009-03-23 | 60 min |
| Season 6 | Episode 9 | The Boy Who Could Break | 2009-03-30 | 60 min |
| Season 6 | Episode 10 | The Black and Blue Baby | 2009-04-06 | 60 min |
| Season 6 | Episode 11 | The Baby Who Couldn't Stop Eating | 2009-04-13 | 60 min |
| Season 6 | Episode 12 | The Girl Who Fell Apart | 2009-04-20 | 60 min |
| Season 6 | Episode 13 | The Girl Who Fell to Pieces | 2009-04-27 | 60 min |
| Season 7 | Episode 1 | The Breasts That Changed Color | 2009-08-10 | 60 min |
| Season 7 | Episode 2 | The Woman Who Saw Pink | 2009-08-17 | 60 min |
| Season 7 | Episode 3 | The Girl with Holes in Her Jaw | 2009-08-24 | 60 min |
| Season 7 | Episode 4 | The Woman Who Went Crazy | 2009-08-31 | 60 min |
| Season 7 | Episode 5 | The Woman Who Couldn't Stop Burping | 2009-09-07 | 60 min |
| Season 8 | Episode 1 | The Boy Who Never Cried | 2009-11-16 | 60 min |
| Season 8 | Episode 2 | The Girl with Half a Face | 2009-11-23 | 60 min |
| Season 8 | Episode 3 | The Girl Who Stopped Growing | 2009-11-30 | 60 min |
| Season 8 | Episode 4 | The Boy with the Strange Stare | 2009-12-07 | 60 min |
| Season 8 | Episode 5 | The Woman Whose Legs Turned Black | 2010-03-08 | 60 min |
| Season 8 | Episode 6 | The Man Who Tripled in Size | 2010-03-15 | 60 min |
| Season 8 | Episode 7 | The Boy Who Couldn't Stop Eating | 2010-03-22 | 60 min |
| Season 8 | Episode 8 | The Girl Who's Skin Came Off | 2010-03-29 | 60 min |
| Season 8 | Episode 9 | The Girl Who Was Covered in Bumps | 2010-04-05 | 60 min |
| Season 8 | Episode 10 | The Baby Who Smelled Like Pancakes | 2010-04-12 | 60 min |
| Season 9 | Episode 1 | The Woman Whose Flesh Was Eaten Alive | 2010-06-07 | 60 min |
| Season 9 | Episode 2 | The Boy Who Only Hopped | 2010-06-14 | 60 min |
| Season 9 | Episode 3 | The Man with Hundreds of Lumps | 2010-06-21 | 60 min |
| Season 9 | Episode 4 | The Baby Who Bruised Easily | 2010-08-09 | 60 min |
| Season 9 | Episode 5 | The Girl with No Bowel | 2010-08-16 | 60 min |
| Season 9 | Episode 6 | The Man Covered in Boils | 2010-08-23 | 60 min |
| Season 9 | Episode 7 | The Toddler That Went Through Puberty | 2010-08-30 | 60 min |
| Season 9 | Episode 8 | The Toddler Who Stopped Walking | 2010-09-06 | 60 min |
| Season 9 | Episode 9 | The Woman with Unusual DNA | 2010-09-20 | 60 min |
| Season 9 | Episode 10 | The Boy with the 150 Pound Leg | 2010-10-04 | 60 min |
| Season 10 | Episode 1 | Fight to the Last Breath | 2011-01-05 | 60 min |
| Season 10 | Episode 2 | Trapped Inside Their Bodies | 2011-01-12 | 60 min |
| Season 10 | Episode 3 | Dangerous Growths | 2011-01-19 | 60 min |
| Season 10 | Episode 4 | When the Body Shuts Down | 2011-01-26 | 60 min |
| Season 10 | Episode 5 | A Family's Desperate Search | 2011-02-02 | 60 min |
| Season 10 | Episode 6 | Time is Running Out | 2011-06-01 | 60 min |
| Season 10 | Episode 7 | Too Young to Be Sick | 2011-06-08 | 60 min |
| Season 10 | Episode 8 | A Search for Answers | 2011-06-15 | 60 min |
| Season 10 | Episode 9 | Stolen Senses | 2011-06-22 | 60 min |
| Season 10 | Episode 10 | Simple Symptoms Turn Threatening | 2011-06-29 | 60 min |