| Season 1 | Episode 1 | Amy Winehouse's Family | 2011-09-12 | 60 min |
| Season 1 | Episode 2 | Kathy Griffin, Snooki & Daniel Radcliffe | 2011-09-13 | 60 min |
| Season 1 | Episode 3 | Abandoned at Birth: Baby Jane Doe & Miraculous Mary | 2011-09-14 | 60 min |
| Season 1 | Episode 4 | Sarah Jessica Parker and the Cast of "I Don't Know How She Does It" | 2011-09-15 | 60 min |
| Season 1 | Episode 5 | Real Housewives of Beverly Hills: After the Tragedy | 2011-09-16 | 60 min |
| Season 1 | Episode 6 | The Story of My Mom: Gloria Vanderbilt | 2011-09-19 | 60 min |
| Season 1 | Episode 7 | Outrageous Custody Battles | 2011-09-20 | 60 min |
| Season 1 | Episode 8 | Conjoined Twins | 2011-09-21 | 60 min |
| Season 1 | Episode 9 | Wallace Jeffs & Former Members of FLDS | 2011-08-22 | 60 min |
| Season 1 | Episode 10 | Jerry & Jessica Seinfeld | 2011-09-23 | 60 min |
| Season 1 | Episode 11 | Twins: Abandoned and Abused | 2011-09-26 | 60 min |
| Season 1 | Episode 12 | Anderson's Food Intervention (1) | 2011-09-27 | 60 min |
| Season 1 | Episode 13 | '50/50' with Seth Rogen, Joseph Gordon-Levitt & Anjelica Huston | 2011-09-28 | 60 min |
| Season 1 | Episode 14 | Former FLDS Teens, Plus Kody Brown & Sister Wives | 2011-09-29 | 60 min |
| Season 1 | Episode 15 | Anna Faris: Was My Ex 'The One'? | 2011-09-30 | 60 min |
| Season 1 | Episode 16 | When Teen Bullying Doesn't Get Better: The Deadly Consequences | 2011-10-03 | 60 min |
| Season 1 | Episode 17 | Second Chances with Paula Abdul, Morgan Freeman and 'America's Got Talent' Winner | 2011-10-04 | 60 min |
| Season 1 | Episode 18 | How Much Would You Pay for a Baby? Black Market Babies | 2011-10-05 | 60 min |
| Season 1 | Episode 19 | Taking Back Your Life From an Abusive Spouse | 2011-10-06 | 60 min |
| Season 1 | Episode 20 | Pet Extravaganza | 2011-10-07 | 60 min |
| Season 1 | Episode 21 | Black Market Babies Scandal | 2011-10-10 | 60 min |
| Season 1 | Episode 22 | Carré Otis | 2011-10-06 | 60 min |
| Season 1 | Episode 23 | Undercover Investigations: Psychics | 2011-10-12 | 60 min |
| Season 1 | Episode 24 | Whom Did I Marry? | 2011-10-13 | 60 min |
| Season 1 | Episode 25 | Big Family Adoption; Dani's Story | 2011-10-14 | 60 min |
| Season 1 | Episode 26 | Can Psychic John Edward Reach Deceased Members of Anderson & Gloria's Family? | 2011-10-17 | 60 min |
| Season 1 | Episode 27 | Are Parents Playing Favorites? | 2011-10-18 | 60 min |
| Season 1 | Episode 28 | Anderson Investigation... Germs | 2011-10-19 | 60 min |
| Season 1 | Episode 29 | Toddlers & Tiaras | 2011-10-20 | 60 min |
| Season 1 | Episode 30 | Meet the Johnstons: One Little Happy Family | 2011-10-21 | 60 min |
| Season 1 | Episode 31 | Anderson's Costco Adventure | 2011-10-24 | 60 min |
| Season 1 | Episode 32 | Stressed Out Family Meets the Simple Life | 2011-10-25 | 60 min |
| Season 1 | Episode 33 | Conquering Your Fears | 2011-10-26 | 60 min |
| Season 1 | Episode 34 | Anderson's Food Intervention (2) | 2011-10-27 | 60 min |
| Season 1 | Episode 35 | Mark Wahlberg Goes Back to His Hometown | 2011-10-28 | 60 min |
| Season 1 | Episode 36 | Is Anderson's House Haunted? | 2011-10-31 | 60 min |
| Season 1 | Episode 37 | Chaz Bono; Toddlers & Tiaras Update; Anderson Teaches Kindergarten | 2011-11-01 | 60 min |
| Season 1 | Episode 38 | Stephanie Madoff Mack Speaks Out; Top Chef Challenge | 2011-11-02 | 60 min |
| Season 1 | Episode 39 | Suburban Polygamy; Viewers' Trash or Treasure; 90-Year-Old Sorority Pledge | 2011-11-03 | 60 min |
| Season 1 | Episode 40 | The Dating Outside Your Race Controversy | 2011-11-04 | 60 min |
| Season 1 | Episode 41 | How to Survive Loss with Gloria Vanderbilt | 2011-11-07 | 60 min |
| Season 1 | Episode 42 | Intervention of a Mom Addicted to Perscription Pills | David Arquette & 'Top Chef' Challenge w/ Padm | 2011-11-08 | 60 min |
| Season 1 | Episode 43 | Scorned lovers Take Revenge on the Internet | Toni Braxton | Utah Motercycle Rescue Reunion | 2011-11-09 | 60 min |
| Season 1 | Episode 44 | Cincinnati Bengals Cheerleader Slander Lawsuit, Nancy Grace talks about 'Dancing w/ the Stars' | 2011-11-10 | 60 min |
| Season 1 | Episode 45 | Judge Spanking Teenage Daughter Goes Viral | Eva Longoria | 2011-11-11 | 60 min |
| Season 1 | Episode 46 | Stop Spending and Start Saving! Plus, Joy Behar | 2011-11-14 | 60 min |
| Season 1 | Episode 47 | Penn State Show | 2011-11-15 | 60 min |
| Season 1 | Episode 48 | Children & Teens Caught in the Wrong Bodies | 2011-11-16 | 60 min |
| Season 1 | Episode 49 | All-American Muslims Debate: How Do You Feel About Muslims Living in the U.S. | 2011-11-17 | 60 min |
| Season 1 | Episode 50 | Sperm Donor Reunion & Hugh Jackman | 2011-11-18 | 60 min |
| Season 1 | Episode 51 | Monster In-Laws; Hottest Holiday Trends With NeNe Leakes | 2011-11-21 | 60 min |
| Season 1 | Episode 52 | Private Lives Exposed; Ellen Barkin; Latest Dancing With the Stars Castoff, Hope Solo | 2011-11-22 | 60 min |
| Season 1 | Episode 53 | Thanksgiving Dinner With Jamie Oliver & Eric Stonestreet | 2011-11-23 | 60 min |
| Season 1 | Episode 54 | Melissa McCarthy; Could You Forgive Someone Who Almost Killed You? The Turkey Lady's Story | 2011-11-28 | 60 min |
| Season 1 | Episode 55 | Dad Gives Daughter Plastic Surgery; Bullying PSA | 2011-11-29 | 60 min |
| Season 1 | Episode 56 | Tracey Gold; Teacher Abuse Caught on Tape; Elton John | 2011-11-30 | 60 min |
| Season 1 | Episode 57 | Hoarders; How to Clutter-Free Your Life | 2011-12-01 | 60 min |
| Season 1 | Episode 58 | Michael Pearl and Extreme Child Discipline; Miracle Dog; Healthy Cooking With Rocco DiSpirito | 2011-12-02 | 60 min |
| Season 1 | Episode 59 | Extreme Measures People Take for Beauty; Sperm Donors Reconnect Through Anderson Show; Dugan Smith U | 2011-12-05 | 60 min |
| Season 1 | Episode 60 | Meredith Vieira & Richard Cohen; Betty White; "The Help's" Octavia Spencer | 2011-12-06 | 60 min |
| Season 1 | Episode 61 | Teacher Abuse Caught on Tape; Stars of Hot in Cleveland | 2011-12-07 | 60 min |
| Season 1 | Episode 62 | Steve Harvey's Relationship Secrets Revealed; Anderson's Family Dinner Challenge Winners | 2011-12-08 | 60 min |
| Season 1 | Episode 63 | Look Your Best for Less With Heidi Klum | 2011-12-09 | 60 min |
| Season 1 | Episode 64 | Angelina Jolie & the Cast of In the Land of Blood and Honey | 2011-12-19 | 60 min |
| Season 1 | Episode 65 | Jane Fonda; Professor Charged With Serving Minors | 2011-12-20 | 60 min |
| Season 1 | Episode 66 | Matt Damon, Scarlett Johansson & the Cast of We Bought a Zoo | 2011-12-21 | 60 min |
| Season 1 | Episode 67 | Anderson's Holiday Show | 2011-12-22 | 60 min |
| Season 1 | Episode 68 | Anderson's New Year's Eve Show With Kathy Griffin & Gloria Vanderbilt | 2011-12-26 | 60 min |
| Season 1 | Episode 69 | Anderson's Resolution Solutions | 2012-01-02 | 60 min |
| Season 1 | Episode 70 | Getting Failure Out of Your Life | 2012-01-04 | 60 min |
| Season 1 | Episode 71 | How Far Is Too Far? | 2012-01-09 | 60 min |
| Season 1 | Episode 72 | Daytime Exclusives: Dance Moms & Inside the Casey Anthony Trial | 2012-01-10 | 60 min |
| Season 1 | Episode 73 | The Mom Debate: Are Stay-at-Home Moms Lazy? Plus, Kathie Lee & Hoda | 2012-01-11 | 60 min |
| Season 1 | Episode 74 | Families in Crisis Over Money & More, Plus Suze Orman | 2012-01-12 | 60 min |
| Season 1 | Episode 75 | Women in Love With Prisoners | 2012-01-13 | 60 min |
| Season 1 | Episode 76 | Are Little Girls Growing Up Too Fast? | 2012-01-16 | 60 min |
| Season 1 | Episode 77 | Headline-Makers: The One-Man Sperm Bank & the Latest Author Phenom | 2012-01-17 | 60 min |
| Season 1 | Episode 78 | Winning the Lottery Ruined My Life; Bayou Billionaires | 2012-01-18 | 60 min |
| Season 1 | Episode 79 | Dolly Parton & the Human Lie Detector | 2012-01-19 | 60 min |
| Season 1 | Episode 80 | Purity: Promise or Myth? | 2012-01-20 | 60 min |
| Season 1 | Episode 81 | Has Your Obsession Gone Too Far? Mother Reveals She Spent Kids' College Tuition | 2012-01-23 | 60 min |
| Season 1 | Episode 82 | Man-imony: Should Women Have to Pay Their Ex-Husbands Alimony? | 2012-01-24 | 60 min |
| Season 1 | Episode 83 | Should You Call the Cops on Your Kids? | 2012-01-25 | 60 min |
| Season 1 | Episode 84 | Your Family's Secret Life: Sex Addiction & Shocking Teen Trends Uncovered | 2012-01-26 | 60 min |
| Season 1 | Episode 85 | What Does Confessed Murderer Joran van der Sloot's Guardian Angel Say Now? | 2012-01-27 | 60 min |
| Season 1 | Episode 86 | Unhappily Ever After: The Business of Divorce | 2012-01-30 | 60 min |
| Season 1 | Episode 87 | Families in Crisis; Is Your House Making You Fat? | 2012-01-31 | 60 min |
| Season 1 | Episode 88 | Katherine Heigl; Honduras Plane Crash Survivors Reunite With Rescuers | 2012-02-01 | 60 min |
| Season 1 | Episode 89 | Madonna: A Daytime Exclusive | 2012-02-02 | 60 min |
| Season 1 | Episode 90 | Drew Barrymore; The Real Story Behind JFK Jr.'s Final Days! | 2012-02-03 | 60 min |
| Season 1 | Episode 91 | My Mom's a Hoarder; Joan & Melissa Rivers | 2012-02-06 | 60 min |
| Season 1 | Episode 92 | OCD Is Ruining My Life; Howie Mandel | 2012-02-07 | 60 min |
| Season 1 | Episode 93 | How My Husband Became My Wife; The Latest Theory on Why Men Cheat | 2012-02-08 | 60 min |
| Season 1 | Episode 94 | Barbara Sheehan; What Would You Do? With John Quiñones | 2012-02-09 | 60 min |
| Season 1 | Episode 95 | Headline-Making Medical Mystery; The Strangest Addictions Ever | 2012-02-10 | 60 min |
| Season 1 | Episode 96 | MTV's Teen Mom and the Real Face of Teen Pregnancy; What Would You Do? With John Quiñones | 2012-02-13 | 60 min |
| Season 1 | Episode 97 | Could You Protect Yourself?; Animal Planet's Pit Boss Shorty Rossi | 2012-02-14 | 60 min |
| Season 1 | Episode 98 | Blended Family Boot Camp | 2012-02-15 | 60 min |
| Season 1 | Episode 99 | Making Money Off of Murder; Public Shaming | 2012-02-16 | 60 min |
| Season 1 | Episode 100 | New Toddlers & Tiaras Controversy | 2012-02-17 | 60 min |
| Season 1 | Episode 101 | Janet Jackson | 2012-02-20 | 60 min |
| Season 1 | Episode 102 | Courteney Cox & the Cast of Cougar Town | 2012-02-21 | 60 min |
| Season 1 | Episode 103 | Should You Be Worried About the End of the World?; Anderson Discusses the Headlines | 2012-02-22 | 60 min |
| Season 1 | Episode 104 | Inside the Mind of a Sex Offender: How to Protect Your Kids | 2012-02-23 | 60 min |
| Season 1 | Episode 105 | The Duggars; Lisa Kudrow & Blair Underwood | 2012-02-24 | 60 min |
| Season 1 | Episode 106 | The Voice's Adam Levine; Trapped in the Wrong Body ... I'm Not Paralyzed | 2012-02-27 | 60 min |
| Season 1 | Episode 107 | Help My Drug-Addicted Daughters; The Latest on Whitney's Daughter, Bobbi Kristina | 2012-02-28 | 60 min |
| Season 1 | Episode 108 | Are Teen Exorcists for Real? Plus, Modern Family's Jesse Tyler Ferguson | 2012-02-29 | 60 min |
| Season 1 | Episode 109 | Life-Shattering Scams: Could It Happen to You? | 2012-03-01 | 60 min |
| Season 1 | Episode 110 | Freaky Food Hoarders; Danny DeVito | 2012-03-02 | 60 min |
| Season 1 | Episode 111 | Anderson's Easy Money Hour | 2012-03-05 | 60 min |
| Season 1 | Episode 112 | Could You Be Fired Over Your Facebook Page?; A Mom's Double Life | 2012-03-06 | 60 min |
| Season 1 | Episode 113 | One-of-a-Kind Primordial Twins | 2012-03-07 | 60 min |
| Season 1 | Episode 114 | Are ADHD Drugs Helping or Hurting Your Kids?; Kristin Davis | 2012-03-08 | 60 min |
| Season 1 | Episode 115 | Julianne Moore; Jack Hanna's Animal Adventures | 2012-03-09 | 60 min |
| Season 1 | Episode 116 | New STD Website Outs People Without Proof or Consent | 2012-03-12 | 60 min |
| Season 1 | Episode 117 | Families of Serial Killers; Olympic Boxing Hopeful Beats the Odds | 2012-03-13 | 60 min |
| Season 1 | Episode 118 | TV's Good Wife, Julianna Margulies & Polygamy Dating Sites | 2012-03-14 | 60 min |
| Season 1 | Episode 119 | Medical Mysteries With Sanjay Gupta; The Muppets' Miss Piggy | 2012-03-15 | 60 min |
| Season 1 | Episode 120 | Where Are They Now? John Ramsey 15 Years After JonBenét's Death | 2012-03-16 | 60 min |
| Season 1 | Episode 121 | Bethenny Frankel; Million-Dollar Female Inventors; DWTS Preview With Tom Bergeron | 2012-03-19 | 60 min |
| Season 1 | Episode 122 | TLC's Little Couple; American Idol Eliminated Contestant | 2012-03-20 | 60 min |
| Season 1 | Episode 123 | Caught on Tape; Ashley Judd | 2012-03-21 | 60 min |
| Season 1 | Episode 124 | The Boy Who Cannot Eat; Kathy Bates | 2012-03-22 | 60 min |
| Season 1 | Episode 125 | The Boy Who Can Not Eat; Mad Med: Jon Hamm & John Slattery | 2012-03-23 | 60 min |
| Season 1 | Episode 126 | Sleep Disorders; Kristin Chenoweth | 2012-03-26 | 60 min |
| Season 1 | Episode 127 | Modern Day Arranged Marriages; The Bully Project | 2012-03-27 | 60 min |
| Season 1 | Episode 128 | American Idol Contestant Castoff; Long Island Medium; Niecy Nash | 2012-03-28 | 60 min |
| Season 1 | Episode 129 | Renegade Moms; Kristen Johnston | 2012-03-29 | 60 min |
| Season 1 | Episode 130 | Miss Robbie & Her Son; Dangerous Distractions: What You Need to Know | 2012-03-30 | 60 min |
| Season 1 | Episode 131 | Outrageous Ways to Save Money; Hypnotism to Lose Weight | 2012-04-09 | 60 min |
| Season 1 | Episode 132 | Obsessed Moms and Extreme Pet-Owners | 2012-04-10 | 60 min |
| Season 1 | Episode 133 | Simple Steps to Change a Habit; Facebook Changed My Life | 2012-04-11 | 60 min |
| Season 1 | Episode 134 | Edie Falco; 85-Year-Old Food Critic | 2012-04-12 | 60 min |
| Season 1 | Episode 135 | My Husband Is a Murderer; How to Spot a Liar | 2012-04-13 | 60 min |
| Season 1 | Episode 136 | Dancing With the Stars Castoff; Natalie Morales and Fran Drescher | 2012-04-16 | 60 min |
| Season 1 | Episode 137 | Daytime Exclusive: Trayvon's Brother & Family Speaks Out; Racism in America | 2012-04-17 | 60 min |
| Season 1 | Episode 138 | Anderson's Fight Lab; Best-Selling Author Nicholas Sparks; American Idol Castoff | 2012-04-18 | 60 min |
| Season 1 | Episode 139 | Daytime Exclusive: My Husband Tried to Kill Me | 2012-04-19 | 60 min |
| Season 1 | Episode 140 | Extreme Groupies vs. Pro Athletes' Wives; Wedding Day Disasters | 2012-04-20 | 60 min |
| Season 1 | Episode 141 | Amazing Stories of Fate, Chance & Luck; Debra Messing | 2012-04-23 | 60 min |
| Season 1 | Episode 142 | I've Been Abducted by Aliens; Topher Grace | 2012-04-24 | 60 min |
| Season 1 | Episode 143 | Anderson's Live Auction & John Cusack | 2012-04-25 | 60 min |
| Season 1 | Episode 144 | Amish: Out of Order; Total Memory Makeover With Marilu Henner | 2012-04-26 | 60 min |
| Season 1 | Episode 145 | DWTS Castoff; True Crime Stories; Anderson's Mystery Guest | 2012-04-27 | 60 min |
| Season 1 | Episode 146 | Co-Host Monday With Kristen Johnston; Private Practice's Kate Walsh | 2012-04-30 | 60 min |
| Season 1 | Episode 147 | Daytime Exclusive: Judi Dench; Anderson Investigates: Why Are We Rude? | 2012-05-01 | 60 min |
| Season 1 | Episode 148 | Straight From the Headlines; Aziz Ansari | 2012-05-02 | 60 min |
| Season 1 | Episode 149 | Suburban Double Life: Mommy Madam's Husband; Vanessa Williams & Mother | 2012-05-03 | 60 min |
| Season 1 | Episode 150 | Daytime Exclusive: Inside the Jailhouse With a Teen Killer | 2012-05-04 | 60 min |
| Season 1 | Episode 151 | Co-Host Monday With Kristin Chenoweth | 2012-05-07 | 60 min |
| Season 1 | Episode 152 | The Truth Behind Deception | 2012-05-08 | 60 min |
| Season 1 | Episode 153 | Sister Wives; Kelly Osbourne; A Surprise From Lady Antebellum | 2012-05-09 | 60 min |
| Season 1 | Episode 154 | Latest Teen Modeling Scams Exposed With Kelly Cutrone; Susan Sarandon | 2012-05-10 | 60 min |
| Season 1 | Episode 155 | Anderson's Mother's Day Show With Gloria Vanderbilt; Chandra Wilson, Jessica Alba and Their Moms | 2012-05-11 | 60 min |
| Season 1 | Episode 156 | Co-Host Monday With Niecy Nash; Andy Cohen; Rosie Perez | 2012-05-14 | 60 min |
| Season 1 | Episode 157 | Jennifer Connelly; A Phobia Is Ruining My Life; Anderson's Spelling Bee | 2012-05-15 | 60 min |
| Season 1 | Episode 158 | Jeopardy; Top 10 Ways to Avoid ID Scams; Debt-Collector Nightmares | 2012-05-16 | 60 min |
| Season 1 | Episode 159 | Bridezilla Intervention With Kim Zolciak; Tennis Champion Serena Williams | 2012-05-17 | 60 min |
| Season 1 | Episode 160 | Suzanne Somers; Caught on Tape | 2012-05-18 | 60 min |
| Season 1 | Episode 161 | Co-Host Rebecca Romijn; Controversial Parenting Methods | 2012-05-21 | 60 min |
| Season 1 | Episode 162 | The New Human Barbie; Men Who Love Dolls | 2012-05-22 | 60 min |
| Season 1 | Episode 163 | Co-Host Ana Gasteyer; Storage Wars; Jimmy Fallon | 2012-05-23 | 60 min |
| Season 1 | Episode 164 | Kevin Costner; I Married Myself | 2012-05-24 | 60 min |
| Season 1 | Episode 165 | Moms Behaving Badly | 2012-05-25 | 60 min |
| Season 1 | Episode 166 | Co-Host Monday With Carrie Ann Inaba | 2012-05-28 | 60 min |
| Season 1 | Episode 167 | Hidden Health Risks; The World's Tallest Man | 2012-05-29 | 60 min |
| Season 1 | Episode 168 | HGH Debate; Kid Phenoms | 2012-05-30 | 60 min |
| Season 1 | Episode 169 | How I Cheated Death; Forced Sterilization | 2012-05-31 | 60 min |
| Season 1 | Episode 170 | The Most Controversial Guests and Outrageous Moments | 2012-06-01 | 60 min |
| Season 2 | Episode 1 | Co-Host Kristin Chenoweth | Honey Boo Boo | Beyonce | 2012-09-10 | 60 min |
| Season 2 | Episode 2 | Co-Host Niecy Nash | Jacqueline Laurita | Human Lie-Detector Janine Driver | 2012-09-11 | 60 min |
| Season 2 | Episode 3 | Co-Host Kelly Osbourne | Ryan Lochte | The Cast of Breaking Amish | 2012-09-12 | 60 min |
| Season 2 | Episode 4 | Co-Host Howie Mandel | William McKee | 2012-09-13 | 60 min |
| Season 2 | Episode 5 | Co-Host David Arquette | Richard Gere | Susan Sarandon & the Cast of Arbitrage | 2012-09-14 | 60 min |
| Season 2 | Episode 6 | Co-Host Tamar Braxton | Emma Watson | The Cast of The Perks of Being a Wallflower | 2012-09-17 | 60 min |
| Season 2 | Episode 7 | Co-Host Deborah Norville | Damien Echols | 2012-09-18 | 60 min |
| Season 2 | Episode 8 | Co-Host Cyndi Lauper | Jon Cryer | The Cast of Bayou Billionaires | 2012-09-19 | 60 min |
| Season 2 | Episode 9 | Co-Host Maria Menounos | Claire Danes | Tom Bergeron | 2012-09-20 | 60 min |
| Season 2 | Episode 10 | Co-Host Retta | Jake Gyllenhaal | Michael Peña | 2012-09-21 | 60 min |
| Season 2 | Episode 11 | Co-Host Goldie Hawn | Athlete Cheryl Leitner | 2012-09-24 | 60 min |
| Season 2 | Episode 12 | Co-Host Katherine Schwarzenegger | Viola Davis | Maggie Gyllenhaal | Rosie Perez & the Cast of Won't | 2012-09-25 | 60 min |
| Season 2 | Episode 13 | Co-Host Kellie Pickler | Kelsey Grammer | Teresa Giudice | 2012-09-26 | 60 min |
| Season 2 | Episode 14 | Co-Host Taraji Henson | Ty Burrell | Dog Whisperer Cesar Millan | 2012-09-27 | 60 min |
| Season 2 | Episode 15 | Co-Host Rosanna Scotto | Carol Burnett | Vicki Lawrence | Tim Conway | Reality-TV stars Bridgette & Brad | 2012-09-28 | 60 min |
| Season 2 | Episode 16 | Co-Host Amy Brenneman | Ramona Singer | 2012-10-01 | 60 min |
| Season 2 | Episode 17 | Co-Host Bethenny Frankel | Anna Kendrick & Brittany Snow | 2012-10-02 | 60 min |
| Season 2 | Episode 18 | Co-Host Martin Short | Julie Bowen | 2012-10-03 | 60 min |
| Season 2 | Episode 19 | Co-Host Andy Cohen | The Cast of Steel Magnolias | 2012-10-04 | 60 min |
| Season 2 | Episode 20 | Co-Host Keke Palmer | Stephen Colbert | 2012-10-05 | 60 min |
| Season 2 | Episode 21 | Co-Host Kellie Pickler | 'X Factor' Alum Chris Rene | 2012-10-08 | 60 min |
| Season 2 | Episode 22 | Co-Host Deborah Norville | Daughter of Alleged 'Coffee Cup Killer' | 2012-10-09 | 60 min |
| Season 2 | Episode 23 | Co-Host Jane Velez-Mitchell | 'Half-Ton Killer' | 1,100-Pound Woman Confesses to Murder | Celebrity Mystery Guest | 2012-10-10 | 60 min |
| Season 2 | Episode 24 | Co-Host Alexa Chung | Human Lie Detector Janine Driver | Kenny Rogers | 2012-10-11 | 60 min |
| Season 2 | Episode 25 | Co-Host Nancy O'Dell | Ben Affleck | John Goodman | Bryan Cranston | 2012-10-12 | 60 min |
| Season 2 | Episode 26 | Co-Host Tasha Smith | Anderson Live's Next Big Idea | Gina & Pat Neely | 2012-10-15 | 60 min |
| Season 2 | Episode 27 | Co-Host Sara Ramirez | Kerry Washington | Cynthia Nixon | 2012-10-16 | 60 min |
| Season 2 | Episode 28 | Co-Host Rachel Dratch | Julie Andrews | 2012-10-17 | 60 min |
| Season 2 | Episode 29 | Co-Host D.L. Hughley | John Edward | Eric LeGrand | 2012-10-18 | 60 min |
| Season 2 | Episode 30 | Co-Host Susan Barnett | Hugh Laurie | Amazing Stories Caught on Tape | 2012-10-19 | 60 min |
| Season 2 | Episode 31 | Co-Host Yvette Nicole Brown | Buyer Beware: We Bought a Meth House | Stump Anderson | 2012-10-22 | 60 min |
| Season 2 | Episode 32 | Co-Host Jane Velez-Mitchell | Janine Driver | True Crime Tuesday | 2012-10-23 | 60 min |
| Season 2 | Episode 33 | Co-Host Lisa Ling | Anderson Live Investigates | 2012-10-24 | 60 min |
| Season 2 | Episode 34 | Co-Host Martina McBride | Secrets from American Pickers | 2012-10-25 | 60 min |
| Season 2 | Episode 35 | Co-Host Suze Orman | Frugal Friday Hour | 2012-10-26 | 60 min |
| Season 2 | Episode 36 | Co-Host Ashleigh Banfield | The Latest on Hurricane Sandy | 2012-10-29 | 60 min |
| Season 2 | Episode 37 | Co-Host Gabrielle Union | Cesar Millan | Ripley's Believe It or Not | 2012-10-30 | 60 min |
| Season 2 | Episode 38 | Co-Host Deborah Norville | The Aftermath of Hurricane Sandy | 2012-11-01 | 60 min |
| Season 2 | Episode 39 | Co-Host Nancy Grace | Phaedra & Porsha from Real Housewives | 2012-11-02 | 60 min |
| Season 2 | Episode 40 | Co-Host Kyle Richards | Krysten Ritter | 2012-11-05 | 60 min |
| Season 2 | Episode 41 | Co-Host Keke Palmer | Election Day | True Crime Tuesday | 2012-11-06 | 60 min |
| Season 2 | Episode 42 | Co-Hosts Meghan McCain & Deborah Norville | Anderson Live's Post Election Day Special | 2012-11-07 | 60 min |
| Season 2 | Episode 43 | Co-Host Keke Palmer | Cheech Marin | Scams | 2012-11-08 | 60 min |
| Season 2 | Episode 44 | Co-Host Iyanla Vanzant | Norman Reedus | 2012-11-09 | 60 min |
| Season 2 | Episode 45 | Co-Host Kelly Osbourne | Kandi Burruss | Extreme Hoarding | 2012-11-12 | 60 min |
| Season 2 | Episode 46 | Co-Host Jane Velez-Mitchell | True Crime Tuesday | Nick Cannon | 2012-11-13 | 60 min |
| Season 2 | Episode 47 | Co-Host Andy Cohen | Adam Levine | 2012-11-14 | 60 min |
| Season 2 | Episode 48 | Co-Host Nicole "Snooki" Polizzi | Bow Wow | 2012-11-15 | 60 min |
| Season 2 | Episode 49 | Co-Host Cynee Simpson | Frugal Friday | 2012-11-16 | 60 min |
| Season 2 | Episode 50 | Co-Host NeNe Leakes | James Spader | 2012-11-19 | 60 min |
| Season 2 | Episode 51 | Co-Host Kathie Lee Gifford & Hoda Kotb | Ashley Greene | 2012-11-20 | 60 min |
| Season 2 | Episode 52 | Anderson Live's Thanksgiving Special | 2012-11-21 | 60 min |
| Season 2 | Episode 53 | Co-Host Caroline Manzo | New Online Danger | Extreme Obsessions | 2012-12-03 | 60 min |
| Season 2 | Episode 54 | Co-Host Christie Brinkley | Gilles Marini | 2012-12-04 | 60 min |
| Season 2 | Episode 55 | Co-Host Meghan McCain | James Van Der Beek | 2012-12-05 | 60 min |
| Season 2 | Episode 56 | Co-Host Stacy London | Bobbi Brown | 2012-12-06 | 60 min |
| Season 2 | Episode 57 | Co-Host Lisa Rinna | Melissa Benoist | 2012-12-07 | 60 min |
| Season 2 | Episode 58 | Co-Host Judy Greer | The Full 60 | 2012-12-10 | 60 min |
| Season 2 | Episode 59 | Co-Host Rosanna Scotto | Medical Mysteries | 2012-12-11 | 60 min |
| Season 2 | Episode 60 | Co-Host Sharon Osbourne | Anderson Live Alert | 2012-12-12 | 60 min |
| Season 2 | Episode 61 | Co-Host Christina Milian | The Full 60 | 2012-12-13 | 60 min |
| Season 2 | Episode 62 | Co-Host Challenge Winner | Frugal Friday | Cast of The Hobbit | 2012-12-14 | 60 min |
| Season 2 | Episode 63 | Co-Host Stacy London | Scam Alert | 2012-12-17 | 60 min |
| Season 2 | Episode 64 | Co-Host Judy Gold | The Full 60 | 2012-12-18 | 60 min |
| Season 2 | Episode 65 | Co-Host Jane Seymour | Gina Gershon | Reality Check | 2012-12-19 | 60 min |
| Season 2 | Episode 66 | Co-Host Rosie Perez | Cast of Downton Abbey | 2012-12-20 | 60 min |
| Season 2 | Episode 67 | Co-Host Leslie Mann | Paul Rudd | Judd Apatow | Winner of The Voice | Frugal Friday | 2012-12-21 | 60 min |
| Season 2 | Episode 68 | Anderson's Christmas Episode | 2012-12-24 | 60 min |
| Season 2 | Episode 69 | Anderson's Live New Year's Eve Special | 2012-12-31 | 60 min |
| Season 2 | Episode 70 | Anderson's Live New Year's Day Special! | 2013-01-01 | 60 min |
| Season 2 | Episode 71 | Co-Host Carmen Electra | 2013 Resolution Solutions | 2013-01-02 | 60 min |
| Season 2 | Episode 72 | Co-Host Melissa Joan Hart | 2013 Resolution Solutions | 2013-01-03 | 60 min |
| Season 2 | Episode 73 | Co-Host Barbara Lee Edwards | Reality Check | Gina Gershon | 2013-01-04 | 60 min |
| Season 2 | Episode 74 | Co-Host Soledad O'Brien | New Online Danger Targeting Women | 2013-01-07 | 60 min |
| Season 2 | Episode 75 | Co-Host Lisa Vanderpump | Betty White | Losing Weight Tips | 2013-01-08 | 60 min |
| Season 2 | Episode 76 | Co-Host Cyndi Lauper | Andrew Rannells | 2013-01-09 | 60 min |
| Season 2 | Episode 77 | Co-Host Marlon Wayans | Bridget Moynahan | Dating Rules in 2013 | 2013-01-10 | 60 min |
| Season 2 | Episode 78 | Co-Host Robin Robinson | Frugal Friday | 2013-01-11 | 60 min |
| Season 2 | Episode 79 | Co-Host T-Boz | Chris Colfer | 2013-01-14 | 60 min |
| Season 2 | Episode 80 | Co-Host Stacy London | Kenya Moore | Clare Bowen | 2013-01-15 | 60 min |
| Season 2 | Episode 81 | Co-Host Dari Alexander | Busy Philipps | 2013-01-16 | 60 min |
| Season 2 | Episode 82 | Co-Host Tatyana Ali | Shorty Rossi & His Dog, Hercules | 2013-01-17 | 60 min |
| Season 2 | Episode 83 | Co-Host D.L. Hughley | Mark Wahlberg | Jeffrey Wright | 2013-01-18 | 60 min |
| Season 2 | Episode 84 | Co-Host Meghan McCain | Josh Gad | 2013-01-21 | 60 min |
| Season 2 | Episode 85 | Co-Host Judge Marilyn Milian | Anderson Live Investigates | 2013-01-22 | 60 min |
| Season 2 | Episode 86 | Co-Host Deborah Tillman | America's Supernanny Helps a Family of Three | 2013-01-23 | 60 min |
| Season 2 | Episode 87 | Co-Host Rosie Perez | Liam McIntyre | 2013-01-24 | 60 min |
| Season 2 | Episode 88 | Co-Host Maria Sansone | Frugal Friday | Animal Planet's Gator Boys | 2013-01-25 | 60 min |
| Season 2 | Episode 89 | Co-Host Emmitt Smith | Online Hoax Alert | 2013-01-28 | 60 min |
| Season 2 | Episode 90 | Co-Host Deborah Norville | Patrick Duffy & Linda Gray | 2013-01-29 | 60 min |
| Season 2 | Episode 91 | Co-Host Jane Velez-Mitchell | Tony Goldwyn | 2013-01-30 | 60 min |
| Season 2 | Episode 92 | Co-Host Stacy London | Hoda Kotb | 2013-01-31 | 60 min |
| Season 2 | Episode 93 | Co-Host Lisa Rinna | Frugal Friday | 2013-02-01 | 60 min |
| Season 2 | Episode 94 | Co-Host Jill Martin | Max Greenfield | 2013-02-04 | 60 min |
| Season 2 | Episode 95 | Co-Host Kimora Lee Simmons | Clare Bowen | 2013-02-05 | 60 min |
| Season 2 | Episode 96 | Co-Host Tiffani Thiessen | Rashida Jones | 2013-02-06 | 60 min |
| Season 2 | Episode 97 | Co-Host Stacy London | Allison Williams | 2013-02-07 | 60 min |
| Season 2 | Episode 98 | Co-Host Toni Braxton | Judith Light | 2013-02-08 | 60 min |
| Season 2 | Episode 99 | Co-Host Jane Velez-Mitchell | Anderson's Oscar Pick | 2013-02-11 | 60 min |
| Season 2 | Episode 100 | Co-Host Regina King | Emmy Rossum | 2013-02-12 | 60 min |
| Season 2 | Episode 101 | Co-Host Fran Drescher | Libby Phelps Alvarez | Inside the Controversial Westboro Baptist Church | 2013-02-13 | 60 min |
| Season 2 | Episode 102 | Co-Host Christie Brinkley | Jackie Collins | Aaron McCargo Jr. | 2013-02-14 | 60 min |
| Season 2 | Episode 103 | Co-Host Brandi Glanville | Josh Duhamel & Julianne Hough | 2013-02-15 | 60 min |
| Season 2 | Episode 104 | Co-Host Willie Geist | Kimora Lee Simmons | 2013-02-18 | 60 min |
| Season 2 | Episode 105 | Co-Host Robin Meade | Psychic Medium Char Margolis | Jennifer Finnigan | 2013-02-19 | 60 min |
| Season 2 | Episode 106 | Co-Host Yvette Nicole Brown | Jillian Michaels | Melissa Rauch | 2013-02-20 | 60 min |
| Season 2 | Episode 107 | Co-Host Patti Stanger | Andrew Zimmern | Mystery Celebrity Guest | 2013-02-21 | 60 min |
| Season 2 | Episode 108 | Co-Host Marilu Henner | Extreme Hoarding Intervention | 2013-02-22 | 60 min |
| Season 2 | Episode 109 | Co-Host Stacy London | Madeleine Stowe | 2013-02-25 | 60 min |
| Season 2 | Episode 110 | Co-Host Kenya Moore | Wendi McLendon-Covey | 2013-02-26 | 60 min |
| Season 2 | Episode 111 | Co-Host Heather McDonald | Al Roker | 2013-02-27 | 60 min |
| Season 2 | Episode 112 | Co-Host La La Anthony | Mom Turned Private Investigator | 2013-02-28 | 60 min |
| Season 2 | Episode 113 | Co-Host Vivica A. Fox | Dulé Hill | 2013-03-01 | 60 min |
| Season 2 | Episode 114 | Co-Host Sunny Hostin | Maggie Q | 2013-03-04 | 60 min |
| Season 2 | Episode 115 | Co-Host Lisa Rinna | Marlee Matlin | 2013-03-05 | 60 min |
| Season 2 | Episode 116 | Co-Host Lisa Rinna | Ricky Schroder | 2013-03-06 | 60 min |
| Season 2 | Episode 117 | Co-Host Molly Sims | Matthew Fox | 2013-03-07 | 60 min |
| Season 2 | Episode 118 | Co-Host Jackée | Katherine Heigl | Extreme OCD | 2013-03-08 | 60 min |
| Season 2 | Episode 119 | Co-Host Daisy Fuentes | Jesse Tyler Ferguson | 2013-03-11 | 60 min |
| Season 2 | Episode 120 | Co-Host Isha Sesay | Rev Run & Actor & Tyrese | Hidden Home Dangers | 2013-03-12 | 60 min |
| Season 2 | Episode 121 | Co-Host Cynthia McFadden | 2013-03-13 | 60 min |
| Season 2 | Episode 122 | Co-Host Tamar Braxton | Trina, Traci, Towanda & Evelyn Braxton | 2013-03-14 | 60 min |
| Season 2 | Episode 123 | Co-Host Padma Lakshmi | Josh Henderson | 2013-03-15 | 60 min |
| Season 2 | Episode 124 | Co-Host Ana Gasteyer | Budget-Friendly Dinner Secrets | 2013-03-18 | 60 min |
| Season 2 | Episode 125 | Co-Host Nicole "Snooki" Polizzi | Meatball Secrets with Owners of The Meatball Shop Restaurant | 2013-03-19 | 60 min |
| Season 2 | Episode 126 | Co-Hosts Nicole "Snooki" Polizzi & Jenni 'JWoww' Farley | Matthew Rhys | 2013-03-20 | 60 min |
| Season 2 | Episode 127 | Co-Host Marilu Henner | Fran Drescher | 2013-03-21 | 60 min |
| Season 2 | Episode 128 | Co-Host Marilyn Milian | Frugal Friday | 2013-03-22 | 60 min |
| Season 2 | Episode 129 | Co-Hosts Marilyn Milian & Vinny Guadagnino | The Duggar Family | 2013-03-25 | 60 min |
| Season 2 | Episode 130 | Co-Host Kyra Phillips | Crazy Obsessions | 2013-03-26 | 60 min |
| Season 2 | Episode 131 | Co-Host Padma Lakshmi | Video Vigilantes Solve Crimes | 2013-03-27 | 60 min |
| Season 2 | Episode 132 | Co-Host Kathy Griffin | Caroline Manzo | 2013-03-28 | 60 min |
| Season 2 | Episode 133 | Co-Host Jill Martin | Julianne Moore | 2013-03-29 | 60 min |
| Season 2 | Episode 134 | Co-Host Andy Cohen | Jessica Walter | 2013-04-05 | 60 min |
| Season 2 | Episode 135 | Seven Little Johnstons | Ask Your Favorite Celebrities | 2013-04-12 | 60 min |
| Season 2 | Episode 136 | Co-Host Jane Pratt | Jesse Metcalfe | 2013-04-15 | 60 min |
| Season 2 | Episode 137 | Co-Host Sunny Anderson | Celebrity Mystery Guest | 2013-04-24 | 60 min |
| Season 2 | Episode 138 | Co-Host Erica Hill | Tim Gunn | 2013-04-25 | 60 min |
| Season 2 | Episode 139 | Co-Host Kathy Griffin | Anderson & Kathy's Truth or Dare Game | 2013-04-26 | 60 min |
| Season 2 | Episode 140 | Co-Host Marilu Henner | Cast of TV Land's Forever Young | 2013-04-29 | 60 min |
| Season 2 | Episode 141 | Co-Host Vivica A. Fox | Dana Delany | 2013-04-30 | 60 min |
| Season 2 | Episode 142 | Ripped from the Headlines: An Entire Hour of True Crime Exclusives | 2013-05-01 | 60 min |
| Season 2 | Episode 143 | Co-Host Norah O'Donnell | Are You a Food Addict? | 2013-05-02 | 60 min |
| Season 2 | Episode 144 | Co-Host Andy Cohen | 3 Ways to Get Out of Debt on Just $10 a Day | 2013-05-03 | 60 min |
| Season 2 | Episode 145 | Co-Host Judy Gold | Amazing Caught-on-Tape Stories | 2013-05-06 | 60 min |
| Season 2 | Episode 146 | Anderson Live's Biggest Newsmakers & Exclusives | 2013-05-07 | 60 min |
| Season 2 | Episode 147 | Co-Host Natalie Morales | Medical Mystery: Boy Who Can't Eat | 2013-05-08 | 60 min |
| Season 2 | Episode 148 | Co-Host Brandy | Wendy Williams | Custody Battle Mistakes | 2013-05-09 | 60 min |
| Season 2 | Episode 149 | Anderson Live's Biggest Surprises & Most Embarrassing Moments | Celebrity Mystery Guest | 2013-05-10 | 60 min |
| Season 2 | Episode 150 | Anderson Live Undercover: Entire Hour of Hidden-Camera Investigations | 2013-05-20 | 60 min |
