| Season 1 | Episode 1 | Russell Brand | 2011-10-10 | 60 min |
| Season 1 | Episode 2 | Wanda Sykes & Gloria Estefan | 2011-10-11 | 60 min |
| Season 1 | Episode 3 | Roseanne Barr | 2011-10-12 | 60 min |
| Season 1 | Episode 4 | Lisa Kudrow | 2011-10-13 | 60 min |
| Season 1 | Episode 5 | Valerie Harper & Kevin Bacon | 2011-10-14 | 60 min |
| Season 1 | Episode 6 | Sharon & Kelly Osbourne & Boyz II Men | 2011-10-17 | 60 min |
| Season 1 | Episode 7 | Fran Drescher & Cheryl Hines | 2011-10-18 | 60 min |
| Season 1 | Episode 8 | Chynna Phillips & Billy Baldwin | 2011-10-19 | 60 min |
| Season 1 | Episode 9 | Cedric the Entertainer & Nancy Grace | 2011-10-20 | 60 min |
| Season 1 | Episode 10 | Behind the Scenes of The Rosie Show | 2011-10-21 | 60 min |
| Season 1 | Episode 11 | Bob Newhart & Tracy Morgan | 2011-10-24 | 60 min |
| Season 1 | Episode 12 | Sara Ramirez & Common | 2011-10-25 | 60 min |
| Season 1 | Episode 13 | Brett Butler | 2011-10-26 | 60 min |
| Season 1 | Episode 14 | Debi Mazar | 2011-10-27 | 60 min |
| Season 1 | Episode 15 | Jerry Ferrara & Gloria Estefan | 2011-10-28 | 60 min |
| Season 1 | Episode 16 | Rosie's Enchanted Halloween | 2011-10-31 | 60 min |
| Season 1 | Episode 17 | Sarah Ferguson | 2011-11-01 | 60 min |
| Season 1 | Episode 18 | Tribute to the Legendary Phyllis Diller | 2011-11-02 | 60 min |
| Season 1 | Episode 19 | Martin Short & Kim Zimmer | 2011-11-03 | 60 min |
| Season 1 | Episode 20 | The Rosie Reality Show | 2011-11-04 | 60 min |
| Season 1 | Episode 21 | Salma Hayek & Antonio Banderas | 2011-11-07 | 60 min |
| Season 1 | Episode 22 | Cyndi Lauper & The Ready, Set, Go! Reveal | 2011-11-08 | 60 min |
| Season 1 | Episode 23 | Lisa Ling & 100 Sets of Twins | 2011-11-09 | 60 min |
| Season 1 | Episode 24 | Florence Henderson & Kool & the Gang | 2011-11-10 | 60 min |
| Season 1 | Episode 25 | Marlee Matlin & Patti LaBelle | 2011-11-11 | 60 min |
| Season 1 | Episode 26 | Rachael Ray & Chaz Bono | 2011-11-14 | 60 min |
| Season 1 | Episode 27 | Cyndi Lauper & Holland Taylor | 2011-11-15 | 60 min |
| Season 1 | Episode 28 | Jenny McCarthy | 2011-11-16 | 60 min |
| Season 1 | Episode 29 | Kody Brown & Sister Wives Meri, Janelle and Christine | 2011-11-17 | 60 min |
| Season 1 | Episode 30 | Ellen Barkin | 2011-11-18 | 60 min |
| Season 1 | Episode 31 | Marlee Matlin & Patti LaBelle | 2011-12-05 | 60 min |
| Season 1 | Episode 32 | Chris Matthews | 2011-12-06 | 60 min |
| Season 1 | Episode 33 | Jim Belushi, Randy Jackson, Henry Winkler, Joan Cusack, Ann Cusack, Nolan Gould | 2011-12-07 | 60 min |
| Season 1 | Episode 34 | Elle Fanning, Colin Ford, Hunter Parrish, the cast of Godspell | 2011-12-08 | 60 min |
| Season 1 | Episode 35 | Dog the Bounty Hunter & Wife Beth Chapman | 2011-12-09 | 60 min |
| Season 1 | Episode 36 | Jane Fonda Tribute | 2011-12-12 | 60 min |
| Season 1 | Episode 37 | Donny and Marie Osmond | 2011-12-13 | 60 min |
| Season 1 | Episode 38 | Justin Bieber | 2011-12-14 | 60 min |
| Season 1 | Episode 39 | Comedy Year in Review | 2011-12-15 | 60 min |
| Season 1 | Episode 40 | It's a Crafty Christmas! | 2011-12-16 | 60 min |
| Season 1 | Episode 41 | A Salute to Penny Marshall | 2012-01-02 | 60 min |
| Season 1 | Episode 42 | An 11-Year-Old Boy's Dream Comes True Plus RuPaul and the Commodores | 2012-01-03 | 60 min |
| Season 1 | Episode 43 | The Rosie Show: Rosie Reality Episode 3 | 2012-01-04 | 60 min |
| Season 1 | Episode 44 | Emmy Rossum, William H. Macy and the Cast of Shameless | 2012-01-05 | 60 min |
| Season 1 | Episode 45 | Game Show Showdown | 2012-01-09 | 60 min |
| Season 1 | Episode 46 | Darrell Hammond & Tori Amos | 2012-01-10 | 60 min |
| Season 1 | Episode 47 | Jackée Harry & Rosie Performs with Styx | 2012-01-11 | 60 min |
| Season 1 | Episode 48 | Louie Anderson & Oksana Baiul | 2012-01-12 | 60 min |
| Season 1 | Episode 49 | Roseanne Cash | 2012-01-13 | 60 min |
| Season 1 | Episode 50 | Miranda Cosgrove and the iCarly Cast | 2012-01-16 | 60 min |
| Season 1 | Episode 51 | NeNe | 2012-01-17 | 60 min |
| Season 1 | Episode 52 | Ricki Lake and the Family Who Saved Rosie | 2012-01-18 | 60 min |
| Season 1 | Episode 53 | Kevin Hart | 2012-01-19 | 60 min |
| Season 1 | Episode 54 | Anthony Baxter and You've Been Trumped | 2012-01-20 | 60 min |
| Season 1 | Episode 55 | Joel Grey, Sutton Foster, and the Broadway Cast of Anything Goes | 2012-01-23 | 60 min |
| Season 1 | Episode 56 | Kathy Griffin, Part 1 | 2012-01-24 | 60 min |
| Season 1 | Episode 57 | Kathy Griffin, Part 2 | 2012-01-25 | 60 min |
| Season 1 | Episode 58 | Joe Rogan | 2012-01-26 | 60 min |
| Season 1 | Episode 59 | Dr. Oz, Part 1 | 2012-01-27 | 60 min |
| Season 1 | Episode 60 | Dr. Oz, Part 2 | 2012-01-30 | 60 min |
| Season 1 | Episode 61 | Dermot Mulroney & Stephanie Izard | 2012-01-31 | 60 min |
| Season 1 | Episode 62 | Jerry Springer | 2012-02-01 | 60 min |
| Season 1 | Episode 63 | Kristin Chenoweth | 2012-02-02 | 60 min |
| Season 1 | Episode 64 | Beth Behrs & Traci Lords | 2012-02-03 | 60 min |
| Season 1 | Episode 65 | Suze Orman | 2012-02-06 | 60 min |
| Season 1 | Episode 66 | Kendra Wilkinson, Hank Baskett & Dakota Goyo | 2012-02-07 | 60 min |
| Season 1 | Episode 67 | Chelsea Handler | 2012-02-08 | 60 min |
| Season 1 | Episode 68 | Ali Wentworth & Ben Clearie | 2012-02-09 | 60 min |
| Season 1 | Episode 69 | Tabatha Coffey, Dakota Goyo, and American Stuffers | 2012-02-10 | 60 min |
| Season 1 | Episode 70 | A Tribute to Tony Bennett | 2012-02-13 | 60 min |
| Season 1 | Episode 71 | Dance Moms | 2012-02-27 | 60 min |
| Season 1 | Episode 72 | Tony Danza & Joe Pantoliano | 2012-02-28 | 60 min |
| Season 1 | Episode 73 | Patti Blagojevich & Chris Errera | 2012-02-29 | 60 min |
| Season 1 | Episode 74 | Teen Moms | 2012-03-01 | 60 min |
| Season 1 | Episode 75 | Audra McDonald and Norm Lewis of Broadway's Porgy and Bess | 2012-03-02 | 60 min |
| Season 1 | Episode 76 | Jenny McCarthy | 2012-03-05 | 60 min |
| Season 1 | Episode 77 | Sandra Bernhard & Rocco DiSpirito | 2012-03-06 | 60 min |
| Season 1 | Episode 78 | Star Jones & Urijah Faber | 2012-03-07 | 60 min |
| Season 1 | Episode 79 | Wayne Brady & Victoria Gotti | 2012-03-08 | 60 min |
| Season 1 | Episode 80 | Nate Phelps & Randy Roberts Potts | 2012-03-09 | 60 min |
| Season 1 | Episode 81 | Liza Minnelli | 2012-03-12 | 60 min |
| Season 1 | Episode 82 | Lance Bass & Ralphie May | 2012-03-13 | 60 min |
| Season 1 | Episode 83 | Suzanne Somers | 2012-03-14 | 60 min |
| Season 1 | Episode 84 | Jaleel White & Debbie Gibson | 2012-03-15 | 60 min |
| Season 1 | Episode 85 | Kat Von D, Zachary Knighton & Eamonn McCrystal | 2012-03-16 | 60 min |
| Season 1 | Episode 86 | Lily Tomlin | 2012-03-19 | 60 min |
| Season 1 | Episode 87 | Bob Harper and Chism Cornelison of The Biggest Loser, Psychic Rebecca Rosen | 2012-03-20 | 60 min |
| Season 1 | Episode 88 | Rosie's 50th Celebrity Birthday Bash - Crystal Bowersox, Chita Rivera, Mariah Carey, Molly Shannon, Kevin Hart, Ricky Martin, Christine Ebersole & Michael Buffer. | 2012-03-21 | 60 min |
| Season 1 | Episode 89 | Mike Tyson | 2012-03-22 | 60 min |
| Season 1 | Episode 90 | Stephen Baldwin & Rachael Harris | 2012-03-23 | 60 min |
| Season 1 | Episode 91 | Natasha Lyonne & Leslie Bibb | 2012-03-26 | 60 min |
| Season 1 | Episode 92 | Storm Large, Mary Johnson & Nell Casey | 2012-03-27 | 60 min |
| Season 1 | Episode 93 | Mackenzie Phillips, Jeff Lewis & Jenni Pulos | 2012-03-28 | 60 min |
| Season 1 | Episode 94 | Eva LaRue, Suzanne Taylor & Josh Kelley | 2012-03-29 | 60 min |
| Season 1 | Episode 95 | Bill and Giuliana Rancic, Plain White T's - Series Finale! | 2012-03-30 | 60 min |
