Main Street Mysteries is a television series airing on Investigation Discovery hosted by Craig Lemons. The first season aired from February 12, 2010 to April 8, 2011.
| Title | Air Date | Duration | ||
|---|---|---|---|---|
| Season 1 | Episode 1 | Vanished | 2010-02-05 | 30 min |
| Season 1 | Episode 2 | Blood Will Tell | 2010-02-05 | 30 min |
| Season 1 | Episode 3 | Over the Edge | 2010-02-12 | 30 min |
| Season 1 | Episode 4 | Deadly Drive | 2010-02-12 | 30 min |
| Season 1 | Episode 5 | Deal Gone Wrong | 2010-02-19 | 30 min |
| Season 1 | Episode 6 | Shattered Innocence | 2010-02-19 | 30 min |
| Season 1 | Episode 7 | Death Comes to Town | 2010-02-26 | 30 min |
| Season 1 | Episode 8 | A Jealous Rage | 2010-02-26 | 30 min |
| Season 1 | Episode 9 | Deadly Neighbor | 2010-03-05 | 30 min |
| Season 1 | Episode 10 | Nine Lives | 2010-03-05 | 30 min |
| Season 1 | Episode 11 | The Key to a Killing | 2010-03-12 | 30 min |
| Season 1 | Episode 12 | A Family Shattered | 2010-03-12 | 30 min |
| Season 1 | Episode 13 | Bitter Betrayal | 2010-03-19 | 30 min |
| Season 1 | Episode 14 | Two of a Kind | 2010-03-26 | 30 min |
| Season 1 | Episode 15 | The Good Son | 2010-04-02 | 30 min |
| Season 1 | Episode 16 | The Man Who Died for Nickels and Dimes | 2010-04-09 | 30 min |
| Season 1 | Episode 17 | Friend for Life...or Death | 2010-04-16 | 30 min |
| Season 1 | Episode 18 | Murder in a Small Town | 2010-04-23 | 30 min |
| Season 1 | Episode 19 | Big Trouble in a Small Town | 2010-04-30 | 30 min |
| Season 1 | Episode 20 | Too Young, Too Evil | 2010-05-07 | 30 min |
| Season 1 | Episode 21 | A Killer; Lost and Found | 2010-05-14 | 30 min |
| Season 1 | Episode 22 | The Blackest Sheep | 2010-05-21 | 30 min |
| Season 1 | Episode 23 | 'Till Death Do Us Part | 2010-05-28 | 30 min |
| Season 1 | Episode 24 | A Mystery in Flames | 2010-06-04 | 30 min |
| Season 1 | Episode 25 | Five Karat Killer | 2010-06-11 | 30 min |
| Season 1 | Episode 26 | Follow the Money | 2010-06-18 | 30 min |
| Season 2 | Episode 1 | Without a Trace | 2010-10-22 | 30 min |
| Season 2 | Episode 2 | Murder in the Dorms | 2010-10-22 | 30 min |
| Season 2 | Episode 3 | Missing Hoosier | 2010-10-29 | 30 min |
| Season 2 | Episode 4 | Before Another Girl Dies | 2010-10-29 | 30 min |
| Season 2 | Episode 5 | In the Line of Duty | 2010-11-05 | 30 min |
| Season 2 | Episode 6 | Where There's Smoke | 2010-11-05 | 30 min |
| Season 2 | Episode 7 | Fade to Murder | 2010-11-12 | 30 min |
| Season 2 | Episode 8 | A Fateful Stop | 2010-11-19 | 30 min |
| Season 2 | Episode 9 | Deadly Obsessions | 2010-12-03 | 30 min |
| Season 2 | Episode 10 | Smoke, Fire and Murder | 2010-12-10 | 30 min |
| Season 2 | Episode 11 | Amid the Ashes | 2010-12-17 | 30 min |
| Season 2 | Episode 12 | Ring of Truth | 2011-01-14 | 30 min |
| Season 2 | Episode 13 | Fortune Teller's Murder | 2011-01-21 | 30 min |
| Season 2 | Episode 14 | The Girl Next Door | 2011-01-28 | 30 min |
| Season 2 | Episode 15 | The Wrong Man | 2011-02-04 | 30 min |
| Season 2 | Episode 16 | The Last Walk | 2011-02-11 | 30 min |
| Season 2 | Episode 17 | Fatal Flames | 2011-02-18 | 30 min |
| Season 2 | Episode 18 | Fall From Grace | 2011-02-25 | 30 min |
| Season 2 | Episode 19 | Deadly Affair | 2011-03-04 | 30 min |
| Season 2 | Episode 20 | The Interstate Prowler | 2011-03-18 | 30 min |
| Season 2 | Episode 21 | Thou Shall Not Kill | 2011-03-25 | 30 min |
| Season 2 | Episode 22 | Unnatural Causes | 2011-04-08 | 30 min |
| Season 2 | Episode 23 | Killer Beside Her | 2011-04-15 | 30 min |
| Season 2 | Episode 24 | Shallow Grave | 2011-04-22 | 30 min |
| Season 2 | Episode 25 | Buried Secrets | 2011-04-29 | 30 min |
| Season 2 | Episode 26 | A Killer Among Us | 2011-05-06 | 30 min |
