Single working mom Christine Campbell has just learned that her ex is dating a much younger woman with the same first name. To avoid any confusion, the new girlfriend is dubbed New Christine, which leaves her with the unfortunate nickname Old Christine.
| Title | Air Date | Duration | ||
|---|---|---|---|---|
| Season 1 | Episode 1 | Pilot | 2006-03-13 | 30 min |
| Season 1 | Episode 2 | Supertramp | 2006-03-13 | 30 min |
| Season 1 | Episode 3 | Open Water | 2006-03-20 | 30 min |
| Season 1 | Episode 4 | One Toe Over the Line, Sweet Jesus | 2006-03-27 | 30 min |
| Season 1 | Episode 5 | I'll Show You Mine | 2006-04-03 | 30 min |
| Season 1 | Episode 6 | The Other F Word | 2006-04-10 | 30 min |
| Season 1 | Episode 7 | A Long Day's Journey Into Stan | 2006-04-17 | 30 min |
| Season 1 | Episode 8 | Teach Your Children Well | 2006-04-24 | 30 min |
| Season 1 | Episode 9 | Ritchie Has Two Mommies | 2006-05-01 | 30 min |
| Season 1 | Episode 10 | No Fault Divorce | 2006-05-08 | 30 min |
| Season 1 | Episode 11 | Exile on Lame Street | 2006-05-15 | 30 min |
| Season 1 | Episode 12 | Some of My Best Friends Are Portuguese | 2006-05-22 | 30 min |
| Season 1 | Episode 13 | A Fair to Remember | 2006-05-22 | 30 min |
| Season 2 | Episode 1 | The Passion of the Christine | 2006-09-18 | 30 min |
| Season 2 | Episode 2 | The Answer is Maybe | 2006-09-25 | 30 min |
| Season 2 | Episode 3 | Come to Papa Jeff | 2006-10-02 | 30 min |
| Season 2 | Episode 4 | Oh God, Yes | 2006-10-09 | 30 min |
| Season 2 | Episode 5 | Separation Anxiety | 2006-10-16 | 30 min |
| Season 2 | Episode 6 | The Champ | 2006-10-23 | 30 min |
| Season 2 | Episode 7 | Playdate with Destiny | 2006-11-06 | 30 min |
| Season 2 | Episode 8 | Women 'N Tuition | 2006-11-13 | 30 min |
| Season 2 | Episode 9 | Mission: Impossible | 2006-11-20 | 30 min |
| Season 2 | Episode 10 | What About Barb? | 2006-11-27 | 30 min |
| Season 2 | Episode 11 | Crash | 2006-12-11 | 30 min |
| Season 2 | Episode 12 | Ritchie Scores | 2007-01-08 | 30 min |
| Season 2 | Episode 13 | Endless Shrimp, Endless Night | 2007-01-15 | 30 min |
| Season 2 | Episode 14 | Let Him Eat Cake | 2007-01-22 | 30 min |
| Season 2 | Episode 15 | Sleepless in Mar Vista | 2007-03-12 | 30 min |
| Season 2 | Episode 16 | Undercover Brother | 2007-03-12 | 30 min |
| Season 2 | Episode 17 | Strange Bedfellows | 2007-03-19 | 30 min |
| Season 2 | Episode 18 | The Real Thing | 2007-04-09 | 30 min |
| Season 2 | Episode 19 | Faith Off | 2007-04-16 | 30 min |
| Season 2 | Episode 20 | My Big Fat Sober Wedding | 2007-04-23 | 30 min |
| Season 2 | Episode 21 | Friends | 2007-04-30 | 30 min |
| Season 2 | Episode 22 | Frasier | 2007-05-07 | 30 min |
| Season 3 | Episode 1 | The Big Bang | 2008-02-04 | 30 min |
| Season 3 | Episode 2 | Beauty Is Only Spanx Deep | 2008-02-11 | 30 min |
| Season 3 | Episode 3 | Popular | 2008-02-18 | 30 min |
| Season 3 | Episode 4 | Traffic | 2008-02-25 | 30 min |
| Season 3 | Episode 5 | Between A Rock And A Hard Place | 2008-03-03 | 30 min |
| Season 3 | Episode 6 | The New Adventures of Old Christine | 2008-03-10 | 30 min |
| Season 3 | Episode 7 | House | 2008-03-10 | 30 min |
| Season 3 | Episode 8 | Burning Down the House | 2008-03-17 | 30 min |
| Season 3 | Episode 9 | The Happy Couple | 2008-03-24 | 30 min |
| Season 3 | Episode 10 | One and a Half Men | 2008-03-31 | 30 min |
| Season 4 | Episode 1 | A Decent Proposal | 2008-09-24 | 30 min |
| Season 4 | Episode 2 | How I Hate Your Mother | 2008-10-01 | 30 min |
| Season 4 | Episode 3 | White Like Me | 2008-10-08 | 30 min |
| Season 4 | Episode 4 | Snakes on a Date | 2008-10-15 | 30 min |
| Season 4 | Episode 5 | Everyone Says I Love You Except Ritchie | 2008-10-22 | 30 min |
| Season 4 | Episode 6 | Tie Me Up, Don't Tie Me Down | 2008-10-29 | 30 min |
| Season 4 | Episode 7 | So You Think You Can Date | 2008-11-05 | 30 min |
| Season 4 | Episode 8 | Self-Esteem Tempura | 2008-11-12 | 30 min |
| Season 4 | Episode 9 | Rage Against the Christine | 2008-11-19 | 30 min |
| Season 4 | Episode 10 | Guess Who's Not Coming to Dinner? | 2008-11-26 | 30 min |
| Season 4 | Episode 11 | Unidentified Funk | 2008-12-10 | 30 min |
| Season 4 | Episode 12 | Happy Endings | 2008-12-17 | 30 min |
| Season 4 | Episode 13 | Notes on a 7th Grade Scandal | 2009-01-14 | 30 min |
| Season 4 | Episode 14 | What Happens In Vegas Is Disgusting In Vegas | 2009-01-21 | 30 min |
| Season 4 | Episode 15 | Reckless Abandonment | 2009-02-11 | 30 min |
| Season 4 | Episode 16 | Honey, I Ran Over the Kid | 2009-02-18 | 30 min |
| Season 4 | Episode 17 | Too Close for Christine | 2009-03-11 | 30 min |
| Season 4 | Episode 18 | A Change of Heart/Pants | 2009-03-18 | 30 min |
| Season 4 | Episode 19 | Hair | 2009-04-08 | 30 min |
| Season 4 | Episode 20 | He Ain't Heavy | 2009-05-06 | 30 min |
| Season 4 | Episode 21 | The Old Maid of Honor | 2009-05-13 | 30 min |
| Season 4 | Episode 22 | Love: A Cautionary Tale | 2009-05-20 | 30 min |
| Season 5 | Episode 1 | Bahamian Rhapsody | 2009-09-23 | 30 min |
| Season 5 | Episode 2 | Burning Love | 2009-09-30 | 30 min |
| Season 5 | Episode 3 | The Mole | 2009-10-07 | 30 min |
| Season 5 | Episode 4 | For Love or Money | 2009-10-14 | 30 min |
| Season 5 | Episode 5 | Dr. Little Man | 2009-10-21 | 30 min |
| Season 5 | Episode 6 | The Curious Case of Britney B | 2009-11-04 | 30 min |
| Season 5 | Episode 7 | Nuts | 2009-11-11 | 30 min |
| Season 5 | Episode 8 | Love Means Never Having to Say You're Crazy | 2009-11-18 | 30 min |
| Season 5 | Episode 9 | I Love Woo, I Hate You | 2009-11-25 | 30 min |
| Season 5 | Episode 10 | Old Christine Meets Young Frankenstein | 2009-12-09 | 30 min |
| Season 5 | Episode 11 | It's Beginning to Stink a Lot Like Christmas | 2009-12-16 | 30 min |
| Season 5 | Episode 12 | A Whale of a Tale | 2010-01-13 | 30 min |
| Season 5 | Episode 13 | Truth or Dare | 2010-01-20 | 30 min |
| Season 5 | Episode 14 | A Family Unfair | 2010-02-10 | 30 min |
| Season 5 | Episode 15 | Sweet Charity | 2010-03-03 | 30 min |
| Season 5 | Episode 16 | Subway, Somehow | 2010-03-10 | 30 min |
| Season 5 | Episode 17 | Up in the Airport | 2010-04-07 | 30 min |
| Season 5 | Episode 18 | Revenge Makeover | 2010-04-14 | 30 min |
| Season 5 | Episode 19 | I Love What You Do For Me | 2010-04-21 | 30 min |
| Season 5 | Episode 20 | Scream | 2010-05-05 | 30 min |
| Season 5 | Episode 21 | Get Smarter | 2010-05-12 | 30 min |
| Production | Jeff Astrof | Co-Executive Producer |
| Production | Andy Ackerman | Producer |
| Production | Sherry Bilsing | Producer |
| Production | Ellen Kreamer | Producer |
| Production | Adam Barr | Producer |
| Production | Julia Louis-Dreyfus | Producer |
| Production | Kari Lizer | Producer |
| Production | Jeff Astrof | Producer |
| Production | Holli Gailen | Producer |
| Production | Holli Gailen | Associate Producer |
| Production | Andy Ackerman | Executive Producer |
| Production | Kari Lizer | Executive Producer |
| Writing | Matt Goldman | Writer |
| Writing | Allan Rice | Writer |
| Writing | Jeff Filgo | Writer |
| Writing | Danielle Evenson | Writer |
| Writing | Jackie Filgo | Writer |
| Writing | Bryan Behar | Writer |
| Writing | Amy Iglow | Writer |
| Writing | Katie Palmer | Writer |
| Writing | Sherry Bilsing | Writer |
| Writing | Frank Pines | Writer |
| Writing | Jeff Astrof | Writer |
| Writing | Steve Baldikoski | Writer |
| Writing | Jack Burditt | Writer |
| Writing | Kari Lizer | Writer |
| Production | Lisa Helfrich | Producer |
| Writing | Ellen Kreamer | Writer |
