| Season 1 | Episode 1 | Steven Tyler | 2012-01-01 | 60 min |
| Season 1 | Episode 2 | Pastor Joel Osteen | 2012-01-08 | 60 min |
| Season 1 | Episode 3 | Governor Chris Christie | 2012-01-15 | 60 min |
| Season 1 | Episode 4 | George Lucas | 2012-01-22 | 60 min |
| Season 1 | Episode 5 | Sean Penn in Haiti | 2012-01-29 | 60 min |
| Season 1 | Episode 6 | Hope in Haiti | 2012-01-30 | 60 min |
| Season 1 | Episode 7 | America's Hidden Culture, Part 1 | 2012-02-12 | 60 min |
| Season 1 | Episode 8 | America's Hidden Culture, Part 2 | 2012-02-13 | 60 min |
| Season 1 | Episode 9 | Tony Robbins | 2012-02-19 | 60 min |
| Season 1 | Episode 10 | Paula Deen | 2012-03-04 | 60 min |
| Season 1 | Episode 11 | Worldwide Exclusive: Oprah Talks to Whitney Houston's Daughter and Family | 2012-03-11 | 60 min |
| Season 1 | Episode 12 | Lady Gaga and Her Mother, Cynthia | 2012-03-18 | 60 min |
| Season 1 | Episode 13 | America's Most Unusual Town | 2012-03-25 | 60 min |
| Season 1 | Episode 14 | Oprah Goes Behind Bars: The South Carolina Mom Who Killed Her Baby Boys | 2012-04-01 | 60 min |
| Season 1 | Episode 15 | Bishop T.D. Jakes | 2012-04-08 | 60 min |
| Season 1 | Episode 16 | Gloria Steinem | 2012-04-15 | 60 min |
| Season 1 | Episode 17 | Oprah Travels to India | 2012-04-22 | 60 min |
| Season 1 | Episode 18 | Women of India | 2012-04-29 | 60 min |
| Season 1 | Episode 19 | Carrie Underwood and Husband Mike Fisher: Their First Interview Together | 2012-05-20 | 60 min |
| Season 1 | Episode 20 | Mayor Cory Booker | 2012-05-27 | 60 min |
| Season 1 | Episode 21 | At Home with Neil Patrick Harris, His Fiancé, David Burtka, and Their Twins | 2012-06-03 | 60 min |
| Season 1 | Episode 22 | Paris Jackson and 50 Cent | 2012-06-10 | 60 min |
| Season 1 | Episode 23 | The Kardashian Family, Part 1 | 2012-06-17 | 60 min |
| Season 1 | Episode 24 | 50 Cent, Part 2 | 2012-06-17 | 60 min |
| Season 1 | Episode 25 | The Kardashian Family, Part 2 | 2012-06-24 | 60 min |
| Season 1 | Episode 26 | NBA Champion Miami Heat Stars LeBron James, Dwyane Wade and Chris Bosh, Part 1 | 2012-07-01 | 60 min |
| Season 1 | Episode 27 | NBA Champion Miami Heat Stars LeBron James, Dwyane Wade and Chris Bosh, Part 2 | 2012-07-08 | 60 min |
| Season 1 | Episode 28 | David Copperfield | 2012-07-15 | 60 min |
| Season 2 | Episode 1 | Oprah Salutes Superstar Olympians | 2012-07-22 | 60 min |
| Season 2 | Episode 2 | Rihanna | 2012-08-19 | 60 min |
| Season 2 | Episode 3 | Kelsey Grammer | 2012-08-26 | 60 min |
| Season 2 | Episode 4 | Olympic Gold Medalist Gabrielle Douglas | 2012-08-26 | 60 min |
| Season 2 | Episode 5 | Jennifer Hudson | 2012-09-09 | 60 min |
| Season 2 | Episode 6 | Usher | 2012-09-16 | 60 min |
| Season 2 | Episode 7 | Stephen Colbert | 2012-09-30 | 60 min |
| Season 2 | Episode 8 | Jason Russell | 2012-10-07 | 60 min |
| Season 2 | Episode 9 | Fergie | 2012-10-21 | 60 min |
| Season 2 | Episode 10 | Bette Midler & Valerie Simpson | 2012-11-11 | 60 min |
| Season 2 | Episode 11 | Justin Bieber: A Worldwide Special | 2012-11-25 | 60 min |
| Season 2 | Episode 12 | Steven Spielberg, Daniel Day-Lewis and Sally Field | 2012-12-02 | 60 min |
| Season 2 | Episode 13 | Kerry Washington and Shonda Rhimes | 2012-12-09 | 60 min |
| Season 2 | Episode 14 | Jamie Foxx, Part 1 | 2012-12-16 | 60 min |
| Season 2 | Episode 15 | Jamie Foxx, Part 2 | 2012-12-16 | 60 min |
| Season 2 | Episode 16 | David Letterman | 2013-01-06 | 60 min |
| Season 2 | Episode 17 | Lance Armstrong, Part 1 | 2013-01-17 | 60 min |
| Season 2 | Episode 18 | Lance Armstrong, Part 2 | 2013-01-18 | 60 min |
| Season 2 | Episode 19 | Drew Barrymore | 2013-01-20 | 60 min |
| Season 2 | Episode 20 | LL Cool J | 2013-01-27 | 60 min |
| Season 2 | Episode 21 | Cissy Houston | 2013-01-28 | 60 min |
| Season 2 | Episode 22 | Beyoncé | 2013-02-16 | 60 min |
| Season 2 | Episode 23 | The Wayans Family | 2013-03-03 | 60 min |
| Season 2 | Episode 24 | Chelsea Handler | 2013-03-10 | 60 min |
| Season 2 | Episode 25 | John of God | 2013-03-17 | 60 min |
| Season 2 | Episode 26 | Sheryl Sandberg & Judge Sonia Sotomayor | 2013-03-24 | 60 min |
| Season 2 | Episode 27 | Jane Fonda & Her Daughter Mary | 2013-04-07 | 60 min |
| Season 2 | Episode 28 | Mark Burnett and Roma Downey Discuss The Bible | 2013-04-14 | 60 min |
| Season 2 | Episode 29 | First Openly Gay NBA Player Jason Collins and His Family | 2013-05-05 | 60 min |
| Season 2 | Episode 30 | Tyler Perry | 2013-05-26 | 60 min |
| Season 2 | Episode 31 | The Voice | 2013-06-02 | 60 min |
| Season 2 | Episode 32 | John Legend and Chrissy Teigen | 2013-06-09 | 60 min |
| Season 2 | Episode 33 | African American Women in Hollywood | 2013-06-23 | 60 min |
| Season 2 | Episode 34 | Hugh Jackman | 2013-07-28 | 60 min |
| Season 2 | Episode 35 | Gloria & Emilio Estefan | 2013-08-04 | 60 min |
| Season 2 | Episode 36 | The Cast of The Butler | 2013-08-11 | 60 min |
| Season 2 | Episode 37 | Lindsay Lohan: The Worldwide Exclusive | 2013-08-18 | 60 min |
| Season 2 | Episode 38 | Tina Turner | 2013-08-25 | 60 min |
| Season 2 | Episode 39 | Robin Thicke | 2013-10-13 | 60 min |
| Season 2 | Episode 40 | Arsenio Hall | 2013-10-20 | 60 min |
| Season 2 | Episode 41 | GAY in Hollywood | 2013-10-27 | 60 min |
| Season 2 | Episode 42 | Patti Labelle | 2013-11-03 | 60 min |
| Season 2 | Episode 43 | Spike Lee | 2013-11-10 | 60 min |
| Season 2 | Episode 44 | Reverend Al Sharpton | 2013-11-17 | 60 min |
| Season 2 | Episode 45 | Kenny | 2013-11-24 | 60 min |
| Season 2 | Episode 46 | Magic Johnson | 2013-12-01 | 60 min |
| Season 2 | Episode 47 | Powerhouse Performances with Idris Elba, Chiwetel Ejiofor and Michael B. Jordan | 2013-12-08 | 60 min |
| Season 3 | Episode 1 | Russell Brand & Heroin Addiction | 2014-03-09 | 60 min |
| Season 3 | Episode 2 | Cameron Diaz & Sharon Stone: Aging Gracefully | 2014-03-16 | 60 min |
| Season 3 | Episode 3 | Kevin Hart | 2014-03-23 | 60 min |
| Season 3 | Episode 4 | Rob Lowe | 2014-04-06 | 60 min |
| Season 3 | Episode 5 | Pharrell Williams | 2014-04-13 | 60 min |
